Aro A, Kyllästinen M, Kostiainen E, Gref C G, Elfving S, Uusitalo U
National Public Health Institute, Helsinki, Finland.
Ann Nutr Metab. 1988;32(3):133-7. doi: 10.1159/000177426.
The influence of dietary supplementation with moderate (200 mg/day) and high (2,000 mg/day) doses of vitamin C on serum lipid levels was studied in 27 female long-stay hospital patients characterized by low plasma ascorbic acid levels during the preceding year. The two doses of vitamin C were compared with placebo in a double-blind, cross-over design during randomly determined 6-week periods followed by 2-week washout intervals. No effect was observed on serum cholesterol, HDL cholesterol, and triglyceride levels. Plasma ascorbic acid levels were highly significantly increased (p less than 0.001) by both doses of vitamin C. It is concluded that dietary supplementation with moderate or high doses of vitamin C does not affect serum lipids of persons who have low plasma ascorbic acid levels suggestive of possible marginal deficiency of vitamin C.
对27名长期住院女性患者进行了研究，这些患者前一年血浆中维生素C水平较低，研究了中等剂量（200毫克/天）和高剂量（2000毫克/天）的维生素C膳食补充剂对血清脂质水平的影响。在随机确定的6周期间采用双盲交叉设计，将这两种剂量的维生素C与安慰剂进行比较，随后有2周的洗脱期。未观察到对血清胆固醇、高密度脂蛋白胆固醇和甘油三酯水平有影响。两种剂量的维生素C均使血浆维生素C水平显著升高（p小于0.001）。得出的结论是，对于血浆维生素C水平较低提示可能存在边缘性维生素C缺乏的人，中等剂量或高剂量的维生素C膳食补充剂不会影响其血清脂质。
