Department of Clinical Sciences Malmö, Lund University, Plastic and Reconstructive Surgery, Skåne University Hospital, SE-20502, Malmö, Sweden.
BMC Psychiatry. 2012 Jul 3;12:74. doi: 10.1186/1471-244X-12-74.
Dercum's disease is characterised by pronounced pain in the adipose tissue and a number of associated symptoms. The condition is usually accompanied by generalised weight gain. Many of the associated symptoms could also be signs of depression. Depression in Dercum's disease has been reported in case reports but has never been studied using an evidence-based methodology. The aim of this study was to examine the presence of depression in patients with Dercum's disease compared to obese controls that do not experience any pain.
A total of 111 women fulfilling the clinical criteria of Dercum's disease were included. As controls, 40 obese healthy women were recruited. To measure depression, the Montgomery Åsberg Depression Rating Scale (MADRS) was used.
According to the total MADRS score, less than half of the patients were classified as having "no depression" (44%), the majority had "light" or "moderate depression" (55%) and one individual had "severe depression" in the Dercum group. In the control groups, the majority of the patients were classified as having "no depression" (85%) and a small number had "light depression" (15%). There was a statistically significant difference for the total MADRS score between the two groups (p = 0.014).
The results indicate that the patients with Dercum's disease are more likely to suffer from depression than controls.
德库姆病的特征是脂肪组织明显疼痛和许多相关症状。这种情况通常伴随着全身性体重增加。许多相关症状也可能是抑郁症的迹象。德库姆病中的抑郁症已在病例报告中报道过，但从未使用循证方法学进行过研究。本研究旨在比较患有德库姆病的患者与不经历任何疼痛的肥胖对照组之间是否存在抑郁。
共纳入 111 名符合德库姆病临床标准的女性。作为对照，招募了 40 名肥胖的健康女性。为了测量抑郁，使用蒙哥马利-Åsberg 抑郁评定量表（MADRS）。
根据总 MADRS 评分，不到一半的患者被归类为“无抑郁”（44%），大多数患者为“轻度”或“中度抑郁”（55%），一名患者为“重度抑郁”。在对照组中，大多数患者被归类为“无抑郁”（85%），少数患者为“轻度抑郁”（15%）。两组之间的总 MADRS 评分存在统计学显著差异（p=0.014）。
结果表明，德库姆病患者比对照组更有可能患有抑郁症。
