Bio-safety Research Center and College of Veterinary Medicine, Chonbuk National University, Jeonju, Republic of Korea.
J Clin Microbiol. 2012 Sep;50(9):3129-32. doi: 10.1128/JCM.00948-12. Epub 2012 Jul 3.
We report a multidrug-resistant strain of Leclercia adecarboxylata responsible for catheter-related bacteremia in a 47-year-old female with breast cancer. The isolated strain was resistant to several β-lactams, aminoglycosides, and folate pathway inhibitors and harbored bla(TEM-1) and bla(CTX-M) group 1 and intl1 genes (dfrA12-orfF-aadA2) as genetic determinants for resistance. Based on a review of the L. adecarboxylata literature, there have been only 4 reports of antibiotic-resistant strains. To our knowledge, this is the first report of an L. adecarboxylata strain with simultaneous resistance to β-lactams, aminoglycosides, and sulfonamides.
我们报告了一例由耐多药莱氏柠檬酸杆菌引起的导管相关菌血症，该菌血症发生在一位 47 岁的乳腺癌女性患者中。分离出的菌株对多种β-内酰胺类、氨基糖苷类和叶酸途径抑制剂均具有耐药性，并且携带 bla(TEM-1)和 bla(CTX-M)组 1 以及 intl1 基因（dfrA12-orfF-aadA2），这些基因是耐药的遗传决定因素。通过对莱氏柠檬酸杆菌文献的回顾，仅有 4 篇关于抗生素耐药菌株的报道。据我们所知，这是首例同时对β-内酰胺类、氨基糖苷类和磺胺类药物具有耐药性的莱氏柠檬酸杆菌菌株报告。
