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过氧化物酶模拟的铋-金纳米粒子用于测定凝血酶的活性和药物筛选。

Peroxidase-mimic bismuth-gold nanoparticles for determining the activity of thrombin and drug screening.

机构信息

Department of Chemistry, National Taiwan University, 1, Section 4, Roosevelt Road, Taipei, 10617, Taiwan.

出版信息

Chem Commun (Camb). 2012 Aug 18;48(64):7952-4. doi: 10.1039/c2cc32833j. Epub 2012 Jul 4.

DOI:10.1039/c2cc32833j
PMID:22760735
Abstract

Fibrinogen-modified bismuth-gold nanoparticles (Fib-Bi-Au NPs) are prepared and used as enzyme mimics for the H(2)O(2)-mediated reaction with Amplex Red (AR), which is further employed for determining thrombin activity and drug screening.

摘要

纤维蛋白原修饰的铋-金纳米粒子(Fib-Bi-Au NPs)被制备并用作酶模拟物,用于与 Amplex Red(AR)介导的 H(2)O(2)反应,进一步用于检测凝血酶活性和药物筛选。

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