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揭示11-MUA涂层对金核氧化铈壳基纳米酶生物相容性和催化活性的影响。

Unveiling the effect of 11-MUA coating on biocompatibility and catalytic activity of a gold-core cerium oxide-shell-based nanozyme.

作者信息

Jain Vidhi, Bhagat Stuti, Singh Mandeep, Bansal Vipul, Singh Sanjay

机构信息

Division of Biological and Life Sciences, School of Arts and Sciences, Ahmedabad University Central Campus Ahmedabad-380009 Gujarat India

Ian Potter NanoBioSensing Facility, NanoBiotechnology Research Laboratory, School of Science, RMIT University Melbourne VIC 3000 Australia.

出版信息

RSC Adv. 2019 Oct 16;9(57):33195-33206. doi: 10.1039/c9ra05547a. eCollection 2019 Oct 15.

DOI:10.1039/c9ra05547a
PMID:35529115
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9073341/
Abstract

The biocompatibility and catalytic activity of nanomaterials exhibiting biological enzyme-like functions (nanozymes) are controlled by shape, size, composition, and surface capping molecules. Although synthesis of multifunctional nanozymes for multiple applications has shown tremendous attraction among researchers worldwide, often their biocompatibility is compromised. In this work, we report the replacement of CTAB by 11-MUA from the surface of a Au-core CeO-shell NP-based nanozyme studied for exhibiting multiple enzyme-like activities such as peroxidase, catalase, and superoxide dismutase. We compared the biocompatibility and enzyme-like activities of CTAB coated Au-core CeO-shell NPs (CSNPs) before and after 11-MUA coating. The catalytic reaction mechanism of peroxidase-like activity of CTAB coated CSNPs was found to be the "Random Bi-Bi", which also remained unaltered after removal of surface CTAB with 11-MUA. The other kinetic parameters, and values, of 11-MUA coated CSNPs were found to be comparable to the CTAB coated NPs.

摘要

具有生物酶样功能的纳米材料（纳米酶）的生物相容性和催化活性受形状、尺寸、组成及表面封端分子的控制。尽管用于多种应用的多功能纳米酶的合成在全球研究人员中展现出了巨大吸引力，但它们的生物相容性常常受到损害。在这项工作中，我们报道了在一种基于金核二氧化铈壳纳米颗粒的纳米酶表面，用11-巯基十一烷酸（11-MUA）取代十六烷基三甲基溴化铵（CTAB），该纳米酶具有过氧化物酶、过氧化氢酶和超氧化物歧化酶等多种酶样活性。我们比较了11-MUA包覆前后CTAB包覆的金核二氧化铈壳纳米颗粒（CSNPs）的生物相容性和酶样活性。发现CTAB包覆的CSNPs的过氧化物酶样活性的催化反应机制为“随机双双”机制，在用11-MUA去除表面CTAB后该机制也保持不变。发现11-MUA包覆的CSNPs的其他动力学参数，即Km和Vmax值，与CTAB包覆的纳米颗粒相当。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/a86af10cd1d9/c9ra05547a-f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/a0811ccfc3f1/c9ra05547a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/dec7f97fad0d/c9ra05547a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/0c5baf2f6309/c9ra05547a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/a86af10cd1d9/c9ra05547a-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/67070f9d2621/c9ra05547a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/3ef5aa5280ab/c9ra05547a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/c9edd25f6cdc/c9ra05547a-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/9bddff828d08/c9ra05547a-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/a0811ccfc3f1/c9ra05547a-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/dec7f97fad0d/c9ra05547a-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/0c5baf2f6309/c9ra05547a-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e8d2/9073341/a86af10cd1d9/c9ra05547a-f8.jpg

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