Yao Xiao-Ying, Lin Yan, Geng Jie-Li, Sun Ya-Meng, Chen Ying, Shi Guo-Wen, Xu Qun, Li Yan-Sheng
Department of Neurology, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200127, China.
Stroke Res Treat. 2012;2012:136398. doi: 10.1155/2012/136398. Epub 2012 Jun 17.
Background. Evidences are accumulating that age and gender have great impact on the distribution of stroke risk factors. Such data are lacking in Chinese population. Methods. 1027 patients with first-ever ischemic stroke (IS) were recruited and divided into young adult (<50 years), middle-aged (50∼80 years), and very old (>80 years) groups according to stroke onset ages. Vascular risk factors were collected and compared among groups. Results. Female patients were globally older than male patients at stroke onset and having higher prevalence of diabetes mellitus (DM), heart diseases, and atrial fibrillation (AF). However, females were less likely to drink heavily or smoke than males. Young patients had a much higher proportion of smoking and drinking than middle-aged and very old patients and the highest family history of hypertension, while very old patients had the highest prevalence of heart diseases and AF but lowest proportion of positive family history of vascular diseases. Hypertension and DM were equally frequent among three groups. Conclusion. Our study showed that vascular risk factors had a specific age and gender distribution pattern in Chinese IS patients. Secondary prevention strategy should emphasize on the control of different risk factors based on patient's age and gender.
背景。越来越多的证据表明，年龄和性别对中风危险因素的分布有很大影响。中国人群缺乏此类数据。方法。招募了1027例首次发生缺血性中风（IS）的患者，并根据中风发病年龄分为青年成人组（<50岁）、中年组（50～80岁）和高龄组（>80岁）。收集血管危险因素并在各组之间进行比较。结果。女性患者在中风发病时总体上比男性患者年龄更大，糖尿病（DM）、心脏病和心房颤动（AF）的患病率更高。然而，女性比男性酗酒或吸烟的可能性更小。年轻患者吸烟和饮酒的比例比中年和高龄患者高得多，高血压家族史最高，而高龄患者心脏病和AF的患病率最高，但血管疾病阳性家族史的比例最低。高血压和DM在三组中同样常见。结论。我们的研究表明，中国IS患者的血管危险因素具有特定的年龄和性别分布模式。二级预防策略应强调根据患者的年龄和性别控制不同的危险因素。
