结核菌素纯化蛋白衍生物——过去、现在与未来
Purified protein derivatives of tuberculin--past, present, and future.
作者信息
Yang Hongliang, Kruh-Garcia Nicole A, Dobos Karen M
机构信息
Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO 80523-1682, USA.
出版信息
FEMS Immunol Med Microbiol. 2012 Dec;66(3):273-80. doi: 10.1111/j.1574-695X.2012.01002.x. Epub 2012 Aug 1.
Abstract
The tuberculin skin test, which involves monitoring the immune reaction to an injection of purified protein derivative (PPD), has been the most widely used method for detecting infection with Mycobacterium tuberculosis since its development in 1930s. Until recently, the molecular composition of PPD was unknown. This thwarted the discovery of improved skin testing reagents and drastically hindered efforts to define the mechanism of action. Proteomic evaluation of PPD combined with a detailed analysis in the guinea pig model of tuberculosis led to further definition of the molecular composition of PPD. This communication reviews the history and current status of PPD, in addition to describing candidate next-generation PPD reagents, based on the use of an individual protein or protein cocktails.
摘要
结核菌素皮肤试验，即监测对注射纯化蛋白衍生物（PPD）的免疫反应，自20世纪30年代开发以来一直是检测结核分枝杆菌感染最广泛使用的方法。直到最近，PPD的分子组成仍不为人知。这阻碍了改进皮肤测试试剂的发现，并严重阻碍了确定其作用机制的努力。对PPD进行蛋白质组学评估，并结合在豚鼠结核病模型中的详细分析，进一步明确了PPD的分子组成。本文除了描述基于使用单个蛋白质或蛋白质混合物的下一代PPD候选试剂外，还回顾了PPD的历史和现状。
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