Department of Neurology, Neuromuscular Division, Washington University School of Medicine, St. Louis, MO, USA.
Ultrasound Med Biol. 2012 Sep;38(9):1618-25. doi: 10.1016/j.ultrasmedbio.2012.04.020. Epub 2012 Jul 3.
Widespread implementation of quantitative muscle ultrasonography in assessing skeletal muscle pathology is limited by an inability to replicate results between different ultrasound systems. We have developed a measurement of skeletal muscle pathology, calibrated muscle backscatter (cMB), which should be reproducible between different ultrasound systems. We compared the reliability of grayscale and cMB measurements between different ultrasound systems, configurations and region-of-interest (ROI) sizes. cMB of skeletal muscle was reliably measured (intraclass correlation coefficient [ICC] ≤0.98) despite very dissimilar grayscale levels (ICC ≤0.54). cMB reliability was highest between systems using similar settings (ICC: 0.82-0.98) and was lowest when transducer type varied (ICC: 0.47-0.71). Reliability was better from ROIs spanning a narrow range of depths compared with larger ranges. cMB measurements are more reliable than grayscale between different ultrasound systems and configurations. Measuring cMB could improve widespread implementation of quantitative ultrasound in assessments of skeletal muscle pathology.
广泛实施定量肌肉超声检查以评估骨骼肌病理受到无法在不同超声系统之间复制结果的限制。我们已经开发出一种骨骼肌病理测量方法,即校准肌肉背散射(cMB),该方法应该在不同的超声系统之间具有可重复性。我们比较了不同超声系统、配置和感兴趣区(ROI)大小之间的灰度和 cMB 测量的可靠性。尽管灰度水平非常不同(ICC≤0.54),但骨骼肌的 cMB 仍能可靠测量(组内相关系数 [ICC]≤0.98)。使用相似设置的系统之间的 cMB 可靠性最高(ICC:0.82-0.98),而当换能器类型不同时,可靠性最低(ICC:0.47-0.71)。与较大范围相比,跨越较窄深度范围的 ROI 的 cMB 测量更可靠。cMB 测量在不同的超声系统和配置之间比灰度更可靠。测量 cMB 可以提高定量超声在评估骨骼肌病理中的广泛应用。