Department of Maternal and Child Health Care, School of Public Health, Shandong University, Jinan, China.
Hypertens Res. 2012 Oct;35(10):1012-8. doi: 10.1038/hr.2012.91. Epub 2012 Jul 5.
A number of studies have reported that sleep duration might have an important role in the development of hypertension. However, the results have been inconsistent. In this study, a meta-analysis was performed to clarify the association between sleep duration and hypertension risk. PubMed, Embase and ISI web of science databases updated on 28 October 2011 were searched for eligible publications. Pooled odds ratio (OR) or relative risk (RR) with 95% confidence intervals (CI) was calculated using a random- or fixed-effect model. Six prospective (N=9959) and seventeen cross-sectional (N=105432) studies were identified for the data analysis on sleep duration. The results indicated that short sleep duration was associated with an increased risk of prevalent hypertension (OR=1.20, 95% CI: 1.09-1.32, P<0.001), especially among subjects younger than 65 years and females. In addition, short sleep duration was also associated with an increased risk of incident hypertension among subjects younger than 65 years (RR=1.33, 95% CI: 1.11-1.61, P=0.002). Overall, there was a significant association between long sleep duration and the risk of prevalent hypertension (OR=1.11, 95% CI: 1.05-1.17, P<0.001). Further subgroup analysis also suggested a significant association between long sleep duration and the risk of prevalent hypertension among subjects younger than 65 years (OR=1.12, 95% CI: 1.06-1.19, P<0.001). The present meta-analysis indicated that short sleep duration was associated with an increased risk of hypertension in the overall polulation and incident hypertension among subjects younger than 65 years. In addition, long sleep duration might be associated with a risk of prevalent hypertension, especially among subjects younger than 65 years.
一些研究报告称，睡眠时间可能在高血压的发展中起着重要作用。然而，结果并不一致。在这项研究中，进行了荟萃分析以阐明睡眠时间与高血压风险之间的关系。检索了 2011 年 10 月 28 日更新的 PubMed、Embase 和 ISI web of science 数据库中的合格出版物。使用随机或固定效应模型计算了合并的比值比（OR）或相对风险（RR）及其 95％置信区间（CI）。对睡眠时间进行数据分析的前瞻性研究有 6 项（N=9959），横断面研究有 17 项（N=105432）。结果表明，睡眠时间短与高血压的患病率增加有关（OR=1.20，95％CI：1.09-1.32，P<0.001），尤其是在年龄小于 65 岁的人群和女性中。此外，睡眠时间短与年龄小于 65 岁的人群中高血压的发生率增加有关（RR=1.33，95％CI：1.11-1.61，P=0.002）。总体而言，睡眠时间长与高血压的患病率增加有关（OR=1.11，95％CI：1.05-1.17，P<0.001）。进一步的亚组分析还表明，睡眠时间长与年龄小于 65 岁的人群中高血压的患病率增加之间存在显著关联（OR=1.12，95％CI：1.06-1.19，P<0.001）。本荟萃分析表明，睡眠时间短与总体人群的高血压风险增加以及年龄小于 65 岁的人群中高血压的发生率增加有关。此外，睡眠时间长可能与高血压的患病率有关，尤其是在年龄小于 65 岁的人群中。
