Płoszyńska Anna, Ruckemann-Dziurdzińska Katarzyna, Jóźwik Agnieszka, Mikosik Anna, Lisowska Katarzyna, Balcerska Anna, Witkowski Jacek M
Department of Pathophysiology, Medical University of Gdansk, Poland.
Folia Histochem Cytobiol. 2012 Jul 5;50(2):304-11. doi: 10.5603/fhc.2012.0040.
Transferrin receptor 1 (CD71) is a transmembrane glycoprotein responsible for cellular iron uptake. Higher expression of CD71 has been identified as a negative prognostic marker for numerous solid tumor types and for some lymphomas. The aim of this study was to evaluate CD71 expression on acute lymphoblastic leukemia (ALL) cells and to follow its possible clinical correlations. Sixty one patients, aged 1-17 years and diagnosed with ALL, were enrolled in the study. CD71 expression was analyzed on the bone marrow blastic cells by flow cytometry. CD71 expression on the leukemic blasts was diversified; in most patients, all blastic cells showed expression of CD71, but levels of expression varied. CD71 expression was statistically higher on T-lineage leukemias. Within the B lineage ALL, a significant difference in CD71 expression existed between precursor B ALL and mature B-ALL, which showed higher CD71 expression. CD71 expression positively correlated with Hgb concentration at diagnosis. Initial risk group assessment and therapy response were not correlated with CD71 expression, although disease free and overall survival times tended to be shorter in patients with B-lineage leukemias with initial high CD71 expression.
转铁蛋白受体1（CD71）是一种负责细胞摄取铁的跨膜糖蛋白。CD71的高表达已被确定为多种实体瘤类型和某些淋巴瘤的不良预后标志物。本研究的目的是评估CD71在急性淋巴细胞白血病（ALL）细胞上的表达，并追踪其可能的临床相关性。61例年龄在1至17岁、诊断为ALL的患者纳入本研究。通过流式细胞术分析骨髓原始细胞上的CD71表达。白血病原始细胞上的CD71表达是多样化的；在大多数患者中，所有原始细胞均显示CD71表达，但表达水平有所不同。T系白血病中CD71表达在统计学上更高。在B系ALL中，前体B-ALL和成熟B-ALL之间的CD71表达存在显著差异，成熟B-ALL显示出更高的CD71表达。CD71表达与诊断时的血红蛋白浓度呈正相关。初始风险组评估和治疗反应与CD71表达无关，尽管初始CD71高表达的B系白血病患者的无病生存期和总生存期往往较短。
