Gerkowicz Agnieszka, Pietrzak Aldona, Szepietowski Jacek Cezary, Radej Sebastian, Chodorowska Grażyna
Department of Dermatology, Venereology and Pediatric Dermatology, Medical University of Lublin, Poland.
Folia Histochem Cytobiol. 2012 Jul 5;50(2):155-70. doi: 10.5603/fhc.2012.0025.
Psoriasis is a chronic immune mediated inflammatory skin disease with a population prevalence of 2-3%. In recent years, psoriasis has been recognized as a systemic disease associated with metabolic syndrome or its components such as: obesity, insulin resistance, hypertension and atherogenic dyslipidemia. Many bioactive substances have appeared to be related to metabolic syndrome. Based on current literature, we here discuss the possible role of adiponectin, leptin, ghrelin, resistin, inflammatory cytokines, plasminogen activator inhibitor 1, uric acid, C-reactive protein and lipid abnormalities in psoriasis and in metabolic syndrome.
银屑病是一种慢性免疫介导的炎症性皮肤病，人群患病率为2%-3%。近年来，银屑病已被公认为是一种与代谢综合征或其组成部分相关的全身性疾病，这些组成部分包括：肥胖、胰岛素抵抗、高血压和致动脉粥样硬化性血脂异常。许多生物活性物质似乎与代谢综合征有关。基于当前文献，我们在此讨论脂联素、瘦素、胃饥饿素、抵抗素、炎性细胞因子、纤溶酶原激活物抑制剂1、尿酸、C反应蛋白和脂质异常在银屑病及代谢综合征中的可能作用。
