Division of Gastroenterology and Hepatology, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Am J Gastroenterol. 2012 Jul;107(7):976-8. doi: 10.1038/ajg.2012.20.
It is generally recommended that patients with nonalcoholic fatty liver disease (NAFLD) not consume alcohol. However, because these patients are at increased cardiovascular risk, and light to moderate alcohol consumption may have hepatic benefits in people with or at risk for NAFLD, this recommendation may be ill-advised. We reviewed the literature on alcohol consumption and NAFLD and conclude that (i) heavy consumption has many harmful effects, including those on the liver, and should be discouraged whether a person has NAFLD or not; (ii) it is unknown whether cardiovascular and metabolic benefits of light to moderate consumption observed in the general population extend to those with NAFLD; (iii) epidemiological and cohort studies suggesting that light to moderate drinking may have hepatic benefits are largely cross-sectional and used surrogate end points; and (iv) until further data from rigorous prospective studies become available, people with NAFLD should avoid alcohol of any type or amount.
一般建议非酒精性脂肪性肝病（NAFLD）患者不要饮酒。但是，由于这些患者心血管风险增加，并且轻至中度饮酒可能对有或有 NAFLD 风险的人具有肝脏益处，因此这种建议可能是不明智的。我们回顾了关于酒精摄入和 NAFLD 的文献，得出以下结论：（i）大量饮酒有许多有害影响，包括对肝脏的影响，无论一个人是否患有 NAFLD，都应予以劝阻；（ii）尚不清楚在普通人群中观察到的轻至中度饮酒对心血管和代谢的益处是否扩展到那些患有 NAFLD 的人群；（iii）提示轻至中度饮酒可能具有肝脏益处的流行病学和队列研究主要是横断面研究，并使用替代终点；以及（iv）在更严格的前瞻性研究提供进一步数据之前，NAFLD 患者应避免任何类型或量的酒精。
