Hussain Nazneen, Igbinedion Samuel O, Diaz Richie, Alexander J S, Boktor Moheb, Knowles Kurt
Department of Gastroenterology and Hepatology, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Department of Internal Medicine, Louisiana State University Health Sciences Center, Shreveport, LA, USA.
Case Reports Hepatol. 2018 Oct 22;2018:8645068. doi: 10.1155/2018/8645068. eCollection 2018.
Liver involvement is a known feature of secondary syphilis. The prevalence of hepatitis in secondary syphilis ranges broadly from 1 to 50%. We report a case of a 37-year-old man with type 1 diabetes mellitus and sickle cell trait presenting with jaundice and acute liver cholestasis. Abdominal ultrasound revealed mild hepatic fatty infiltration. RPR and Treponema pallidum IgG results were positive with a reflex titer of 1:64. Liver biopsy revealed chronic hepatitis with normal hepatic architecture, Kupffer cell hyperplasia, hepatic cholestasis, and ductal proliferation suggestive of syphilitic hepatitis.
肝脏受累是二期梅毒的一个已知特征。二期梅毒中肝炎的患病率范围广泛，从1%到50%不等。我们报告一例37岁男性病例，该患者患有1型糖尿病和镰状细胞性状，表现为黄疸和急性肝内胆汁淤积。腹部超声显示轻度肝脏脂肪浸润。快速血浆反应素试验（RPR）和梅毒螺旋体IgG结果呈阳性，滴度为1:64。肝活检显示为慢性肝炎，肝结构正常，库普弗细胞增生，肝内胆汁淤积以及导管增生，提示为梅毒性肝炎。
