Yu Yong-Zhong, Wu Zhi-Jun, Zhu Zhan-Bo, Pan Qiu-Zhen, Cui Yu-Dong
College of Life Science and Biotechnology, Heilongjiang Bayi Agricultural University, Daqing 163319, China.
Bing Du Xue Bao. 2012 May;28(3):278-84.
Contagious ecthyma (also known as orf) is an acute skin zoonosis caused by orf virus (ORFV), which affects sheep, goats and humans. As one of the typical species of the Parapoxvirus genus of the Poxviridae family, orf virus has distinctive and unique characteristics of these species. A range of immuno-modulatory/pathogenesis -related genes acquired by virus that function is to limit (at least transiently) the effectiveness of host immunity during its evolution. This review is aimed to describe the latest progress on the molecular characteristics of ORFV, and upon which we analyzed molecular mechanism of the immune escape designed and a set of strategies developed for ORFV to effective against immune clearance of the host. Known as an essential component in evolutionary system, host is regulated by ORFV for using in population evolution. By the ORFV evolutional immune regulation components and its effect approach, we can understand the viral biological characteristics of ORFV, and it is helpful for us to further study the counter-measures of this disease.
传染性脓疱病（也称为羊口疮）是由羊口疮病毒（ORFV）引起的一种急性皮肤人畜共患病，可感染绵羊、山羊和人类。作为痘病毒科副痘病毒属的典型物种之一，羊口疮病毒具有这些物种独特的特征。病毒获得了一系列免疫调节/发病机制相关基因，其功能是在进化过程中（至少暂时）限制宿主免疫的有效性。本综述旨在描述羊口疮病毒分子特征的最新进展，并在此基础上分析其免疫逃逸的分子机制，以及为有效对抗宿主免疫清除而开发的一套针对羊口疮病毒的策略。宿主作为进化系统的重要组成部分，受到羊口疮病毒的调控以用于种群进化。通过羊口疮病毒进化免疫调节成分及其作用途径，我们可以了解羊口疮病毒的病毒生物学特性，这有助于我们进一步研究该疾病的应对措施。
