UCP1-3826A/G 多态性对肥胖和血压的性别依赖性影响。
Sex-dependent effects of the UCP1 -3826 A/G polymorphism on obesity and blood pressure.
机构信息
Obesity Research Unit, Physiological Anthropology Laboratory, Department of Anthropology, University of Delhi, Delhi.
出版信息
Ethn Dis. 2012 Spring;22(2):181-4.
OBJECTIVE
To ascertain the association of -3826 A/G polymorphism with blood pressure and different obesity markers.
DESIGN AND SUBJECTS
A total of 96 adult participants (49 males, 47 females) were studied. Anthropometric measurements and blood pressure were taken using standardized techniques. Obesity indices of body mass index (BMI), waist hip ratio (WHR), waist height ratio (WHtR) and grand mean thickness (GMT) were computed. For genetic analysis, DNA was extracted from 50 microL blood.
RESULTS
A statistically significant difference between various genotypes of UCP1 and BMI, GMT, systolic blood pressure, diastolic blood pressure was found among females. In GGC homozygote, blood pressure showed positive and significant association with fat percentage and GMT (P < .001). Waist circumference, WHR, WHtR and BMI also showed positive association with blood pressure in heterozygous and homozygous GG form.
CONCLUSION
This study links the GG homozygous form of UCP1 with obesity and blood pressure among females only.
目的
确定 -3826A/G 多态性与血压和不同肥胖标志物的关联。
设计和研究对象
共研究了 96 名成年参与者（49 名男性，47 名女性）。使用标准化技术进行人体测量和血压测量。计算了体重指数（BMI）、腰臀比（WHR）、腰围身高比（WHtR）和平均厚度（GMT）等肥胖指数。为了进行基因分析，从 50 微升血液中提取了 DNA。
结果
在女性中，UCP1 的各种基因型与 BMI、GMT、收缩压和舒张压之间存在统计学显著差异。在 GGC 纯合子中，血压与脂肪百分比和 GMT 呈正相关且显著（P<.001）。在杂合和纯合 GG 形式中，腰围、WHR、WHtR 和 BMI 也与血压呈正相关。
结论
本研究仅将 UCP1 的 GG 纯合形式与女性的肥胖和血压联系起来。
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