Holmes B, Yamada E W
Enzyme. 1979;24(3):188-96. doi: 10.1159/000458653.
Weight loss and reduction in specific activity of cytochrome oxidase of both red (soleus) and white muscles (gastrocnemius and plantaris) of the rat was greatest 5 days after sciatic nerve crush (p less than 0.001) and then became minimal. In neither was there a significant, concomitant loss of protein. By 19 days, the specific activity of cytochrome oxidase was the same in both muscle types. The specific activity of lactate dehydrogenase was reduced significantly (p less than 0.001) in the white muscles, to a value approaching that of the red soleus by 19 days postoperatively, but remained unaltered in the soleus. Nerve crush is proposed as a model experimental system for studying neural regulation of skeletal muscle metabolism.
大鼠坐骨神经挤压伤后5天，红色（比目鱼肌）和白色肌肉（腓肠肌和跖肌）的体重减轻以及细胞色素氧化酶的比活性降低最为明显（p<0.001），随后降至最低。两种肌肉中均未出现明显的蛋白质伴随性损失。到第19天，两种肌肉类型中细胞色素氧化酶的比活性相同。白色肌肉中乳酸脱氢酶的比活性显著降低（p<0.001），术后19天时接近红色比目鱼肌的值，但比目鱼肌中的该酶活性保持不变。提出神经挤压伤作为研究骨骼肌代谢神经调节的模型实验系统。
