Division of Dermatology, Department of Internal Related, Kobe University Graduate School of Medicine, 7-5-1, Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
J Dermatol Sci. 2012 Oct;68(1):3-8. doi: 10.1016/j.jdermsci.2012.06.006. Epub 2012 Jun 23.
Human epidermal keratinocytes are located on the body surface, which is a specialized location for component cells of human skin tissue. Those cells are always exposed to external stimuli, which constantly generate reactive oxygen species (ROS) in the cells. Regulation of the redox state is a key for maintaining intracellular homeostasis. Originally, each cell type has defensive systems against oxidative stress, thus keratinocytes may have a unique system for regulating ROS levels. Intracellular signaling appropriately reacts to changes of ROS in cooperation with intra- and extra-cellular antioxidant agents, and is sometimes affected by excessive ROS generated by various stresses. We review in this paper the impact of ROS on keratinocytes based on published data and focus on related signaling pathways involved in inflammation and oncogenesis.
人类表皮角质形成细胞位于体表，这是人体皮肤组织成分细胞的一个特殊位置。这些细胞经常暴露在外部刺激下，细胞内会不断产生活性氧（ROS）。氧化还原状态的调节是维持细胞内稳态的关键。最初，每种细胞类型都有针对氧化应激的防御系统，因此角质形成细胞可能具有独特的 ROS 调节系统。细胞内信号与细胞内外抗氧化剂一起适当响应 ROS 的变化，并且有时会受到各种应激产生的过多 ROS 的影响。本文基于已发表的数据，综述了 ROS 对角质形成细胞的影响，并重点介绍了与炎症和癌变相关的信号通路。
