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甲型H1N1流感疫苗接种会导致膜性肾小球肾炎吗?

Can influenza H1N1 vaccination lead to the membranous glomerulonephritis?

作者信息

Kutlucan Ali, Gonen Ibak, Yildizhan Esra, Aydin Yusuf, Sav Tansu, Yildirim Umran

机构信息

Department of Infectious Diseases, Duzce University, Faculty of Medicine, Duzce, Turkey.

出版信息

Indian J Pathol Microbiol. 2012 Apr-Jun;55(2):239-41. doi: 10.4103/0377-4929.97893.

Abstract

In 2009 winter, Influenza A (H1N1) monovalent split virus vaccine was used prevalently in the whole world as a result of the pandemic caused by Influenza (H1N1) virus. The vaccine's adverse effects were observed closely and vaccination has been found as safe in most studies. But some reports about immune response related diseases after influenza vaccinations are remarkable. The close relationship between membranous glomerulonephritis and antigens is known, particularly in seconder forms which occur after viral infections and vaccinations. So this case report is about a 56-year-old man, who developed membranous glomerulonephritis 23 days after the vaccination against Influenza A (H1N1) virus.

摘要

2009年冬季,由于甲型H1N1流感病毒引发的大流行,甲型H1N1流感单价裂解病毒疫苗在全球普遍使用。对该疫苗的不良反应进行了密切观察,并且在大多数研究中已发现接种疫苗是安全的。但是,关于流感疫苗接种后免疫反应相关疾病的一些报告值得关注。膜性肾小球肾炎与抗原之间的密切关系是已知的,特别是在病毒感染和疫苗接种后出现的继发性形式中。因此,本病例报告是关于一名56岁男性,他在接种甲型H1N1流感病毒疫苗23天后患上了膜性肾小球肾炎。

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