甲型流感（H1N1）感染导致的系膜增生性肾小球肾炎合并急性肾小管间质性肾炎，进而引发急性肾损伤。
Mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis leading to acute kidney injury in influenza A (H1N1) infection.
作者信息
Kute V B, Vanikar A V, Shah P R, Gumber M R, Patel H V, Trivedi H L
机构信息
Department of Nephrology and Clinical Transplantation, Transfusion Services and Immunohematology, Institute of Kidney Diseases and Research Centre, Dr. H L Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.
Department of Pathology, Laboratory Medicine, Transfusion Services and Immunohematology, Institute of Kidney Diseases and Research Centre, Dr. H L Trivedi Institute of Transplantation Sciences, Ahmedabad, Gujarat, India.
出版信息
Indian J Nephrol. 2014 Mar;24(2):114-6. doi: 10.4103/0971-4065.127902.
Respiratory complications and renal failure are the leading causes for morbidity and mortality due to influenza (H1N1) virus infection. There has been limited information on histopathology of H1N1 influenza-related acute kidney injury (AKI). We describe AKI with H1N1 infection in a 52-year-old female. Renal biopsy showed mesangial proliferative glomerulonephritis with acute tubule interstitial nephritis. Her condition improved rapidly with oseltamivir, fluid replacement, steroid and dialysis. Our case suggests that H1N1 infection may have a causative link to the development of mesangial proliferative glomerulonephritis with acute tubulointerstitial nephritis.
呼吸并发症和肾衰竭是甲型H1N1流感病毒感染导致发病和死亡的主要原因。关于甲型H1N1流感相关急性肾损伤（AKI）的组织病理学信息有限。我们描述了一名52岁女性感染甲型H1N1流感后的急性肾损伤情况。肾活检显示为系膜增生性肾小球肾炎合并急性肾小管间质性肾炎。使用奥司他韦、补液、类固醇和透析治疗后，她的病情迅速好转。我们的病例表明，甲型H1N1流感感染可能与系膜增生性肾小球肾炎合并急性肾小管间质性肾炎的发生存在因果关系。
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