远端增强子介导的转录调控：谁参与其中？
Transcription regulation by distal enhancers: who's in the loop?
作者信息
Stadhouders Ralph, van den Heuvel Anita, Kolovos Petros, Jorna Ruud, Leslie Kris, Grosveld Frank, Soler Eric
机构信息
Department of Cell Biology; Erasmus Medical Center, Rotterdam, The Netherlands.
出版信息
Transcription. 2012 Jul-Aug;3(4):181-6. doi: 10.4161/trns.20720. Epub 2012 Jul 1.
Abstract
Genome-wide chromatin profiling efforts have shown that enhancers are often located at large distances from gene promoters within the noncoding genome. Whereas enhancers can stimulate transcription initiation by communicating with promoters via chromatin looping mechanisms, we propose that enhancers may also stimulate transcription elongation by physical interactions with intronic elements. We review here recent findings derived from the study of the hematopoietic system.
摘要
全基因组染色质分析结果表明，增强子通常位于非编码基因组中距离基因启动子很远的位置。虽然增强子可以通过染色质环化机制与启动子进行通讯来刺激转录起始，但我们提出，增强子也可能通过与内含子元件的物理相互作用来刺激转录延伸。我们在此回顾近期造血系统研究得出的发现。
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