Department of Medicine, Massachusetts General Hospital, Boston MA, USA.
J Acquir Immune Defic Syndr. 2012 Aug 1;60 Suppl 2(Suppl 2):S39-40. doi: 10.1097/QAI.0b013e318258bc9f.
Antiretroviral therapy has transformed the management of HIV-infected individuals over the past quarter century. However, important challenges remain. These include attempts to eradicate HIV from reservoirs within the body, thereby eliminating the need for lifetime therapy. In addition, improvements in drug development, clinical trial, and regulatory pathways are necessary to expeditiously evaluate novel therapeutic regimens and strategies. Antiretroviral drug scarcity remains a major problem in underserved populations worldwide, and partnerships among pharmaceutical companies, academic investigators, and both governmental and nongovernmental agencies are necessary to improve access to these life-saving regimens.
抗逆转录病毒疗法在过去的四分之一个世纪改变了 HIV 感染者的管理方式。然而，仍然存在重要的挑战。这些挑战包括试图从体内的储库中根除 HIV，从而消除终身治疗的需要。此外，还需要改进药物开发、临床试验和监管途径，以迅速评估新的治疗方案和策略。抗逆转录病毒药物短缺仍然是全球服务不足人群的一个主要问题，制药公司、学术研究人员以及政府和非政府机构之间的伙伴关系对于改善这些救命疗法的可及性是必要的。
