Unidad de Investigación del Hospital General Yague, Avenida del Cid, 96, 09005 Burgos, Spain.
Mol Biol Rep. 2012 Oct;39(10):9355-60. doi: 10.1007/s11033-012-1760-3. Epub 2012 Jul 8.
Our aim was to investigate the effect of chemotherapy on plasma total antioxidant capacity and polyphenols in patients with colon cancer. Plasma samples were collected from 70 CRC patients under chemotherapy treatment, and 15 non-treated patients. The control group included 71 healthy individuals. Plasma ABTS and FRAP were measured as biomarkers of antioxidant total capacity and the total phenols as an indicator to determine the polyphenols levels in plasma. Treatment with chemotherapy protocols resulted in a significant decrease of ABTS (-24 %, p < 0.048), FRAP (-15 %, p < 0.046) and polyphenols (-46 %, p < 0.05) compared with the values of those not treated. The total antioxidant capacity was significantly lower (-18 % for ABTS and -12 % for FRAP) in patients with metastasis as compared with patients without metastasis. The plasma total phenols, were also decreased (-16 %, p = 0.005) in metastasis patients. The patients with colorectal cancer have decreased total antioxidant capacity and the values are lower in patients treated with chemotherapy. Furthermore, CEA tumor marker levels are associated with a lower plasma total antioxidant capacity, and therefore with the progress and development of the disease.
我们的目的是研究化疗对结肠癌患者血浆总抗氧化能力和多酚的影响。从 70 名接受化疗治疗的 CRC 患者和 15 名未接受治疗的患者中采集血浆样本。对照组包括 71 名健康个体。使用 ABTS 和 FRAP 作为衡量总抗氧化能力的生物标志物，用总酚作为衡量血浆中多酚水平的指标。与未接受治疗的患者相比，化疗方案治疗导致 ABTS（-24%，p<0.048）、FRAP（-15%，p<0.046）和多酚（-46%，p<0.05）水平显著下降。与无转移患者相比，转移患者的总抗氧化能力显著降低（ABTS 降低 18%，FRAP 降低 12%）。血浆总酚也降低（转移患者降低 16%，p=0.005）。结直肠癌患者的总抗氧化能力降低，且接受化疗的患者值更低。此外，CEA 肿瘤标志物水平与较低的血浆总抗氧化能力相关，因此与疾病的进展和发展相关。
