酰胺活化促进烯酰胺与炔烃或芳炔的偶联反应合成取代吡啶和异喹啉。
Coupling of enamides with alkynes or arynes for synthesis of substituted pyridines and isoquinolines via amide activation.
机构信息
Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, Department of Chemistry & Materials Science, Northwest University, Xi'an 710069, PR China.
出版信息
Chem Commun (Camb). 2012 Aug 21;48(65):8105-7. doi: 10.1039/c2cc33768a. Epub 2012 Jul 6.
PMID:22772801
Abstract
A novel and general procedure for Cu-catalyzed coupling of enamides with alkynes to synthesize substituted pyridines was developed. The chemistry was allowed to extend to the synthesis of substituted isoquinolines by coupling of enamides with arynes under transition-metal-free conditions.
摘要
发展了一种新颖且通用的方法，通过铜催化酰胺与炔烃的偶联反应来合成取代吡啶。在无过渡金属条件下，酰胺与芳炔偶联，该化学方法扩展到取代异喹啉的合成。
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