Artner J, Leucht F, Cakir B, Reichel H, Lattig F
Orthopädische Universitätsklinik Ulm am RKU, Oberer Eselsberg 45, 89081 Ulm, Deutschland.
Orthopade. 2012 Nov;41(11):889-93. doi: 10.1007/s00132-012-1966-z.
Spinal epidural lipomatosis (SEL) is a rare condition affecting the thoracic and lumbar spine, characterized by a hypertrophy and hyperplasia of the rich vascularized fat tissue inside the spinal canal. The etiology of SEL is unknown. A high number of cases are associated with obesity, corticosteroid intake and a dysbalance in adrenocorticotropic hormone (ACTH)-cortisone metabolism. It can be an incidental radiographic finding or present with symptoms, such as low back pain, weakness of the lower limbs, dysesthesia, radiculopathy, claudication or even cauda equina syndrome. The interdisciplinary treatment consists of weight reduction, weaning from corticosteroids and in persisting cases or neurologic alterations in surgical decompression of the spinal canal. The following article presents a current review and a case report of this rare entity.
脊髓硬膜外脂肪增多症(SEL)是一种累及胸段和腰段脊柱的罕见疾病,其特征是椎管内富含血管的脂肪组织肥大和增生。SEL的病因尚不清楚。大量病例与肥胖、皮质类固醇摄入以及促肾上腺皮质激素(ACTH)-可的松代谢失衡有关。它可以是偶然的影像学发现,也可以表现出如腰痛、下肢无力、感觉异常、神经根病、间歇性跛行甚至马尾综合征等症状。多学科治疗包括减重、停用皮质类固醇,对于持续存在的病例或有神经功能改变的情况则进行椎管减压手术。以下文章对这种罕见疾病进行了综述并报告了一例病例。