Abdel-Sattar Essam A, Mouneir Samar M, Asaad Gihan F, Abdallah Hossam M
1Department of Pharmacognosy, Faculty of Pharmacy, Cairo University, Cairo, Egypt.
Toxicol Ind Health. 2014 Mar;30(2):147-53. doi: 10.1177/0748233712452601. Epub 2012 Jul 6.
The aqueous and methanolic extracts of Calligonum comosum were investigated for their antioxidant and dopaminergic effects on haloperidol (HL)-induced neuro- and hepatotoxicities in male albino rat model. The total phenolics, flavonoid content and free radical-scavenging activity of the extracts were determined. The results showed that the antioxidant activity of the methanolic extract was higher than the aqueous one. HL significantly reduced GSH and increased MDA in brain and liver tissues. These values were nearly normalized, in the examined tissues, on concomitant administration of C. comosum methanolic extract with HL. Superoxide dismutase activity in the examined tissues was significantly decreased by HL administration that was normalized by the coadministration of the methanolic extract and, to a less extent, the water extract. Determination of the brain neurotransmitter contents revealed a marked decrease in norepinephrine, dopamine and serotonin, which were restored to near control values by concomitant administration of both C. comosum extracts with HL. The results of this study showed that C. comosum methanolic and aqueous extracts ameliorated HL-induced neuro- and hepatotoxicities in rats.
研究了沙拐枣的水提取物和甲醇提取物对雄性白化大鼠模型中氟哌啶醇（HL）诱导的神经毒性和肝毒性的抗氧化和多巴胺能作用。测定了提取物的总酚含量、黄酮含量和自由基清除活性。结果表明，甲醇提取物的抗氧化活性高于水提取物。HL显著降低了脑和肝组织中的谷胱甘肽（GSH）含量并增加了丙二醛（MDA）含量。在与HL同时给予沙拐枣甲醇提取物后，所检测组织中的这些值几乎恢复正常。HL给药显著降低了所检测组织中的超氧化物歧化酶（SOD）活性，而甲醇提取物与水提取物共同给药在一定程度上可使其恢复正常。对脑神经递质含量的测定显示，去甲肾上腺素、多巴胺和5-羟色胺显著减少，而沙拐枣两种提取物与HL同时给药可使其恢复至接近对照值。本研究结果表明，沙拐枣甲醇提取物和水提取物可改善HL诱导的大鼠神经毒性和肝毒性。
