• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

在具有 ABCC2 基因座突变的抗性小菜蛾种群中，Cry1Fa 缺乏与中肠刷状缘膜的结合。

Lack of Cry1Fa binding to the midgut brush border membrane in a resistant colony of Plutella xylostella moths with a mutation in the ABCC2 locus.

机构信息

Departamento de Genética, Facultad de CC. Biológicas, Universidad de Valencia, Burjassot, Valencia, Spain.

出版信息

Appl Environ Microbiol. 2012 Sep;78(18):6759-61. doi: 10.1128/AEM.01689-12. Epub 2012 Jul 6.

DOI:10.1128/AEM.01689-12
PMID:22773634
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3426719/
Abstract

Previous studies reported "mode 1" Bacillus thuringiensis resistance in a colony of diamondback moths (NO-QA), and recently, this resistance has been mapped to an ABC transporter (ABCC2) locus. We report the lack of binding of Cry1Fa to insects derived from this colony and compare our data with those from other insects with ABCC2-associated resistance.

摘要

先前的研究报道了小菜蛾（NO-QA）群体中的“模式 1”苏云金芽孢杆菌抗性，并最近将该抗性映射到 ABC 转运蛋白（ABCC2）基因座。我们报告了源自该群体的昆虫与 Cry1Fa 的结合缺失，并将我们的数据与具有 ABCC2 相关抗性的其他昆虫的数据进行了比较。

相似文献

1
Lack of Cry1Fa binding to the midgut brush border membrane in a resistant colony of Plutella xylostella moths with a mutation in the ABCC2 locus.在具有 ABCC2 基因座突变的抗性小菜蛾种群中，Cry1Fa 缺乏与中肠刷状缘膜的结合。
Appl Environ Microbiol. 2012 Sep;78(18):6759-61. doi: 10.1128/AEM.01689-12. Epub 2012 Jul 6.
2
CRISPR/Cas9-mediated knockout of both the PxABCC2 and PxABCC3 genes confers high-level resistance to Bacillus thuringiensis Cry1Ac toxin in the diamondback moth, Plutella xylostella (L.).CRISPR/Cas9 介导的 PxABCC2 和 PxABCC3 基因敲除赋予小菜蛾对苏云金芽孢杆菌 Cry1Ac 毒素的高水平抗性。
Insect Biochem Mol Biol. 2019 Apr;107:31-38. doi: 10.1016/j.ibmb.2019.01.009. Epub 2019 Jan 30.
3
ABCC2 is associated with Bacillus thuringiensis Cry1Ac toxin oligomerization and membrane insertion in diamondback moth.ABCC2 与苏云金芽孢杆菌 Cry1Ac 毒素寡聚化和在小菜蛾中的膜插入有关。
Sci Rep. 2017 May 24;7(1):2386. doi: 10.1038/s41598-017-02545-y.
4
CRISPR-Mediated Knockout of the Gene in Confers High-Level Resistance to the Cry1Fa Toxin.CRISPR 介导的基因敲除赋予对Cry1Fa 毒素的高水平抗性。
Toxins (Basel). 2020 Apr 11;12(4):246. doi: 10.3390/toxins12040246.
5
Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.鳞翅目昆虫对苏云金芽孢杆菌毒素抗性的平行进化。
Genetics. 2011 Oct;189(2):675-9. doi: 10.1534/genetics.111.130971. Epub 2011 Aug 11.
6
Insecticidal activity of Bacillus thuringiensis Cry1Bh1 against Ostrinia nubilalis (Hubner) (Lepidoptera: Crambidae) and other lepidopteran pests.苏云金芽孢杆菌Cry1Bh1对欧洲玉米螟（Hubner）（鳞翅目：草螟科）及其他鳞翅目害虫的杀虫活性。
Appl Environ Microbiol. 2013 Dec;79(24):7590-7. doi: 10.1128/AEM.01979-13. Epub 2013 Sep 27.
7
Independent and Synergistic Effects of Knocking out Two ABC Transporter Genes on Resistance to Toxins Cry1Ac and Cry1Fa in Diamondback Moth.敲除两个ABC转运蛋白基因对小菜蛾抗Cry1Ac和Cry1Fa毒素的独立及协同作用
Toxins (Basel). 2020 Dec 24;13(1):9. doi: 10.3390/toxins13010009.
8
Altered Glycosylation of 63- and 68-kilodalton microvillar proteins in Heliothis virescens correlates with reduced Cry1 toxin binding, decreased pore formation, and increased resistance to Bacillus thuringiensis Cry1 toxins.烟草天蛾中63千道尔顿和68千道尔顿微绒毛蛋白的糖基化改变与Cry1毒素结合减少、孔形成减少以及对苏云金芽孢杆菌Cry1毒素的抗性增加相关。
Appl Environ Microbiol. 2002 Nov;68(11):5711-7. doi: 10.1128/AEM.68.11.5711-5717.2002.
9
Analysis of the Effect of and Transporter on Cry1Ac Susceptibility by CRISPR/Cas9-Mediated Knockout.利用 CRISPR/Cas9 介导的基因敲除技术分析 和 转运蛋白对 Cry1Ac 敏感性的影响。
Toxins (Basel). 2023 Apr 6;15(4):273. doi: 10.3390/toxins15040273.
10
Expressing a moth abcc2 gene in transgenic Drosophila causes susceptibility to Bt Cry1Ac without requiring a cadherin-like protein receptor.在转基因果蝇中表达蛾类abcc2基因会使其对Bt Cry1Ac敏感，且无需类钙黏蛋白受体。
Insect Biochem Mol Biol. 2017 Jan;80:61-70. doi: 10.1016/j.ibmb.2016.11.008. Epub 2016 Nov 30.

引用本文的文献

1
Resistance of Lepidopteran Pests to Toxins: Evidence of Field and Laboratory Evolved Resistance and Cross-Resistance, Mode of Resistance Inheritance, Fitness Costs, Mechanisms Involved and Management Options.鳞翅目害虫对毒素的抗性：田间和实验室进化抗性和交叉抗性的证据、抗性遗传模式、适合度代价、涉及的机制和管理选择。
Toxins (Basel). 2024 Jul 12;16(7):315. doi: 10.3390/toxins16070315.
2
Which Is Stronger? A Continuing Battle Between Cry Toxins and Insects.哪种更强大？苏云金芽孢杆菌晶体毒素与昆虫之间的持续较量。
Front Microbiol. 2021 Jun 1;12:665101. doi: 10.3389/fmicb.2021.665101. eCollection 2021.
3
The ABCC2 Acts as a Cry1A Receptor Independently of its Nucleotide Binding Domain II.ABCC2 作为 Cry1A 受体发挥作用，不依赖于其核苷酸结合域 II。
Toxins (Basel). 2019 Mar 22;11(3):172. doi: 10.3390/toxins11030172.
4
Efficacy and Resistance Management Potential of a Modified Vip3C Protein for Control of Spodoptera frugiperda in Maize.新型 Vip3C 蛋白对玉米草地贪夜蛾的防治效果及抗药性管理潜力
Sci Rep. 2018 Nov 1;8(1):16204. doi: 10.1038/s41598-018-34214-z.
5
Characterization and expression profiling of ATP-binding cassette transporter genes in the diamondback moth, Plutella xylostella (L.).小菜蛾（Plutella xylostella (L.)）中ATP结合盒转运蛋白基因的特征分析与表达谱研究
BMC Genomics. 2016 Sep 27;17(1):760. doi: 10.1186/s12864-016-3096-1.
6
Synergism and antagonism between Bacillus thuringiensis Vip3A and Cry1 proteins in Heliothis virescens, Diatraea saccharalis and Spodoptera frugiperda.苏云金芽孢杆菌Vip3A与Cry1蛋白在绿铃夜蛾、甘蔗二点螟和草地贪夜蛾中的协同作用与拮抗作用
PLoS One. 2014 Oct 2;9(9):e107196. doi: 10.1371/journal.pone.0107196. eCollection 2014.
7
Alkaline phosphatases and aminopeptidases are altered in a Cry11Aa resistant strain of Aedes aegypti.碱性磷酸酶和氨肽酶在埃及伊蚊的Cry11Aa抗性品系中发生了改变。
Insect Biochem Mol Biol. 2014 Nov;54:112-21. doi: 10.1016/j.ibmb.2014.09.004. Epub 2014 Sep 19.
8
Alternative splicing and highly variable cadherin transcripts associated with field-evolved resistance of pink bollworm to bt cotton in India.与印度棉铃虫对转Bt基因棉花的田间进化抗性相关的可变剪接和高度可变的钙黏蛋白转录本
PLoS One. 2014 May 19;9(5):e97900. doi: 10.1371/journal.pone.0097900. eCollection 2014.
9
The impact of strain diversity and mixed infections on the evolution of resistance to Bacillus thuringiensis.菌株多样性和混合感染对苏云金芽孢杆菌抗药性进化的影响。
Proc Biol Sci. 2013 Sep 4;280(1769):20131497. doi: 10.1098/rspb.2013.1497. Print 2013 Oct 22.
10
Shared midgut binding sites for Cry1A.105, Cry1Aa, Cry1Ab, Cry1Ac and Cry1Fa proteins from Bacillus thuringiensis in two important corn pests, Ostrinia nubilalis and Spodoptera frugiperda.苏云金芽胞杆菌 Cry1A.105、Cry1Aa、Cry1Ab、Cry1Ac 和 Cry1Fa 蛋白在两种重要玉米害虫棉铃虫和草地贪夜蛾中的共有中肠结合位点。
PLoS One. 2013 Jul 5;8(7):e68164. doi: 10.1371/journal.pone.0068164. Print 2013.

本文引用的文献

1
Single amino acid mutation in an ATP-binding cassette transporter gene causes resistance to Bt toxin Cry1Ab in the silkworm, Bombyx mori.一个 ATP 结合盒转运蛋白基因中的单个氨基酸突变导致家蚕对 Bt 毒素 Cry1Ab 的抗性。
Proc Natl Acad Sci U S A. 2012 Jun 19;109(25):E1591-8. doi: 10.1073/pnas.1120698109. Epub 2012 May 25.
2
Specific binding of radiolabeled Cry1Fa insecticidal protein from Bacillus thuringiensis to midgut sites in lepidopteran species.苏云金芽孢杆菌 Cry1Fa 杀虫蛋白放射性标记物与鳞翅目昆虫中肠部位的特异性结合。
Appl Environ Microbiol. 2012 Jun;78(11):4048-50. doi: 10.1128/AEM.07591-11. Epub 2012 Mar 23.
3
Differential alteration of two aminopeptidases N associated with resistance to Bacillus thuringiensis toxin Cry1Ac in cabbage looper.小菜蛾对苏云金芽孢杆菌 Cry1Ac 毒素抗性相关的两种氨肽酶 N 的差异改变。
Proc Natl Acad Sci U S A. 2011 Aug 23;108(34):14037-42. doi: 10.1073/pnas.1102555108. Epub 2011 Aug 15.
4
Parallel evolution of Bacillus thuringiensis toxin resistance in lepidoptera.鳞翅目昆虫对苏云金芽孢杆菌毒素抗性的平行进化。
Genetics. 2011 Oct;189(2):675-9. doi: 10.1534/genetics.111.130971. Epub 2011 Aug 11.
5
An ABC transporter mutation is correlated with insect resistance to Bacillus thuringiensis Cry1Ac toxin.一种 ABC 转运蛋白突变与昆虫对苏云金芽孢杆菌 Cry1Ac 毒素的抗性相关。
PLoS Genet. 2010 Dec 16;6(12):e1001248. doi: 10.1371/journal.pgen.1001248.
6
Binding site alteration is responsible for field-isolated resistance to Bacillus thuringiensis Cry2A insecticidal proteins in two Helicoverpa species.结合部位改变是导致两种烟夜蛾物种对苏云金芽孢杆菌 Cry2A 杀虫蛋白产生田间分离抗性的原因。
PLoS One. 2010 Apr 1;5(4):e9975. doi: 10.1371/journal.pone.0009975.
7
Field-evolved insect resistance to Bt crops: definition, theory, and data.田间进化的昆虫对 Bt 作物的抗性：定义、理论和数据。
J Econ Entomol. 2009 Dec;102(6):2011-25. doi: 10.1603/029.102.0601.
8
Mechanism of resistance to Bacillus thuringiensis toxin Cry1Ac in a greenhouse population of the cabbage looper, Trichoplusia ni.温室中粉纹夜蛾Trichoplusia ni对苏云金芽孢杆菌毒素Cry1Ac的抗性机制
Appl Environ Microbiol. 2007 Feb;73(4):1199-207. doi: 10.1128/AEM.01834-06. Epub 2006 Dec 22.
9
Cross-Resistance to Bacillus thuringiensis Toxin CryIF in the Diamondback Moth (Plutella xylostella).小菜蛾对苏云金芽孢杆菌 CryIF 毒素的交互抗性。
Appl Environ Microbiol. 1994 Dec;60(12):4627-9. doi: 10.1128/aem.60.12.4627-4629.1994.
10
Mutations in the Bacillus thuringiensis Cry1Ca toxin demonstrate the role of domains II and III in specificity towards Spodoptera exigua larvae.苏云金芽孢杆菌Cry1Ca毒素中的突变表明了结构域II和III在对甜菜夜蛾幼虫特异性方面的作用。
Biochem J. 2004 Dec 15;384(Pt 3):507-13. doi: 10.1042/BJ20041094.