Liu Lin, Ling Shi-Qi, Li Qiao-Li, Wang Tao, Ye Hui, Yang Jie-Zhen, Jia Xiu-Hua
General Hospital of Guangzhou Military Command of Chinese PLA, Guangzhou 510010, Guangdong Province, China.
Int J Ophthalmol. 2012;5(3):312-6. doi: 10.3980/j.issn.2222-3959.2012.03.12. Epub 2012 Jun 18.
To examine the relations between lymphangiogenesis and the size of pterygium.
Tissues from 88 primary and 34 recurrent pterygia were evaluated, and those from 7 nasal epibulbar conjunctiva segments were used as controls. Pterygium slices from each patient were stained with LYVE-1 monoclonal antibodies to identify lymphatic microvessel for calculating lymph-vascular area (LVA), lymph-microvascular density (LMD) and lymph-vascular luminal diameter (LVL). Also, the relations between lymphangiogenesis (measuring by LVA, LMD and LVL) and the size of pterygium (extension, width and area) were explored.
There were a few LYVE-1((+)) lymphatic vessels in normal epibulbar conjunctiva segments. However, the number of lymphatic vessels slightly increased in primary pterygia and dramatically increased in recurrent pterygia. LVA, LMD and LVL significantly increased in recurrent pterygia in comparison with primary pterygia (all P<0.05). Both LMD and LVA were correlated with the width and area of pterygia (both P< 0.05), and LVA was also correlated with the extension of pterygia(P<0.05).
Lymphangiogenesis is correlated with the size of pterygium. The outgrowth of lymphatic vessels might contribute to the development of pterygia.
探讨淋巴管生成与翼状胬肉大小之间的关系。
对88例原发性翼状胬肉组织和34例复发性翼状胬肉组织进行评估，并将7例鼻侧球结膜组织作为对照。对每位患者的翼状胬肉切片用LYVE-1单克隆抗体进行染色，以识别淋巴管微血管，计算淋巴管面积（LVA）、淋巴微血管密度（LMD）和淋巴管腔直径（LVL）。此外，还探讨了淋巴管生成（通过LVA、LMD和LVL测量）与翼状胬肉大小（伸展度、宽度和面积）之间的关系。
正常球结膜组织中有少量LYVE-1（+）淋巴管。然而，原发性翼状胬肉中淋巴管数量略有增加，而复发性翼状胬肉中淋巴管数量显著增加。与原发性翼状胬肉相比，复发性翼状胬肉的LVA、LMD和LVL显著增加（均P<0.05）。LMD和LVA均与翼状胬肉的宽度和面积相关（均P<0.05），LVA也与翼状胬肉的伸展度相关（P<0.05）。
淋巴管生成与翼状胬肉大小相关。淋巴管的增生可能有助于翼状胬肉的发展。
