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复发性翼状胬肉中血管生成与淋巴管生成的关系。

Relationship between angiogenesis and lymphangiogenesis in recurrent pterygium.

作者信息

Qi Chao-Xiu, Zhang Xiao-Dong, Yuan Jin, Yang Jie-Zhen, Sun Yi, Wang Tao, Ye Hui, Ling Shi-Qi

机构信息

Department of Ophthalmology, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, Guangdong Province, China.

出版信息

Int J Ophthalmol. 2012;5(6):655-60. doi: 10.3980/j.issn.2222-3959.2012.06.01. Epub 2012 Dec 18.

Abstract

AIM

To examine the relationship between angiogenesis and lymphangigenesis in recurrent pterygia.

METHODS

Tissues from 34 excised recurrent pterygia (including 12 Grade 1, 10 Grade 2, and 12 Grade 3) were involved in the study and tissues from 7 nasal epibulbar conjunctivae segments were used as controls. Sections from each pterygium were immunostained with CD(31) and LYVE-1 monoclonal antibodies to evaluate lymphatic microvessel density (LMVD) and blood microvessel density (BMVD), and the relationship between LMVD and BMVD in the pterygium was examined.

RESULTS

There was a large number of CD(31) ((+))LYVE-1((-)) blood vessels but only a few CD(31) ((+))LYVE-1((+)) lymphatic vessels in grades 1 and 2 pterygium. However, lymphatic vessels were dramatically increased in grade 3 pterygium. LMVD correlated closely with BMVD in all pterygia, including grades 1, 2 and 3 peterygium patients (all P values <0.01). Although both the density of blood and lymphatic vessels increased in recurrent pterygia, lymphatic vessels developed much faster than blood vessels, especially in grade 3 pterygia.

CONCLUSION

There is a significant but not parallel relationship between angiogenesis and lymphangiogenesis in recurrent pterygium. The outgrowth of blood and lymphatic vessels provide evidence that immunological mechanism may play a role in the development and recurrence of pterygium.

摘要

目的

探讨复发性翼状胬肉中血管生成与淋巴管生成之间的关系。

方法

本研究纳入34例切除的复发性翼状胬肉组织(包括12例1级、10例2级和12例3级),并以7个鼻侧球结膜节段组织作为对照。对每个翼状胬肉切片用CD(31)和LYVE-1单克隆抗体进行免疫染色,以评估淋巴管微血管密度(LMVD)和血管微血管密度(BMVD),并研究翼状胬肉中LMVD与BMVD之间的关系。

结果

在1级和2级翼状胬肉中有大量CD(31)((+))LYVE-1((-))血管,但只有少数CD(31)((+))LYVE-1((+))淋巴管。然而,3级翼状胬肉中的淋巴管显著增多。在所有翼状胬肉中,包括1级、2级和3级翼状胬肉患者,LMVD与BMVD密切相关(所有P值<0.01)。虽然复发性翼状胬肉中血管和淋巴管密度均增加,但淋巴管的发育比血管快得多,尤其是在3级翼状胬肉中。

结论

复发性翼状胬肉中血管生成与淋巴管生成之间存在显著但不平行的关系。血管和淋巴管的生长为免疫机制可能在翼状胬肉的发生和复发中起作用提供了证据。

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