Department of Pathology, Bacteriology and Avian Diseases, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium.
Vet Microbiol. 2012 Dec 7;160(3-4):449-54. doi: 10.1016/j.vetmic.2012.06.031. Epub 2012 Jun 27.
Helicobacter suis is a zoonotically important bacterium, that has been associated with gastritis and ulcerative lesions of the pars oesophagea of the stomach in pigs. Its exact role in these pathologies, however, still remains controversial. Therefore, a total of 29 medicated early weaned piglets were inoculated intragastrically or orally, with a total of 2 × 10(9) viable H. suis bacteria and the effect on gastric pathology and weight gain was determined. Twenty-three medicated early weaned piglets were inoculated with a sterile culture medium and used as sham-inoculated controls. The animals were euthanized between 28 and 42 days after inoculation. Infected animals showed a more severe gastritis compared to the control group. There was also a significant reduction of approximately 60 g per day (10%) in weight gain in H. suis inoculated animals compared to the sham-inoculated control animals. In conclusion, this study demonstrates for the first time that a pure in vitro culture of H. suis not only causes gastritis but also a marked decrease of the daily weight gain in experimentally infected pigs.
猪幽门螺杆菌是一种重要的人畜共患病细菌，与猪胃食管部的胃炎和溃疡性病变有关。然而，其在这些病理中的确切作用仍存在争议。因此，共将 29 头用药物进行早期断奶的小猪进行了胃内或口服接种，接种的总活菌数为 2×10(9)个猪幽门螺杆菌，以确定其对胃病理和体重增加的影响。将 23 头用无菌培养基进行了接种的用药物进行早期断奶的小猪作为假接种对照。接种后 28 至 42 天之间对动物进行了安乐死。与对照组相比，感染动物表现出更严重的胃炎。与假接种对照组相比，接种猪幽门螺杆菌的动物的体重增加每天减少约 60 克（10%）。总之，本研究首次证明，猪幽门螺杆菌的纯体外培养不仅会引起胃炎，还会显著降低实验感染猪的每日体重增加。
