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猪的粪便微生物群与甲型流感病毒疫苗接种反应之间的联系。

Links between fecal microbiota and the response to vaccination against influenza A virus in pigs.

作者信息

Borey Marion, Blanc Fany, Lemonnier Gaëtan, Leplat Jean-Jacques, Jardet Deborah, Rossignol Marie-Noëlle, Ravon Laure, Billon Yvon, Bernard Maria, Estellé Jordi, Rogel-Gaillard Claire

机构信息

Université Paris-Saclay, INRAE, AgroParisTech, GABI, Jouy-en-Josas, France.

INRAE, GenESI, Surgères, France.

出版信息

NPJ Vaccines. 2021 Jul 22;6(1):92. doi: 10.1038/s41541-021-00351-2.

DOI:10.1038/s41541-021-00351-2
PMID:34294732
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8298503/
Abstract

This study describes the associations between fecal microbiota and vaccine response variability in pigs, using 98 piglets vaccinated against the influenza A virus at 28 days of age (D28) with a booster at D49. Immune response to the vaccine is measured at D49, D56, D63, and D146 by serum levels of IAV-specific IgG and assays of hemagglutination inhibition (HAI). Analysis of the pre-vaccination microbiota characterized by 16S rRNA gene sequencing of fecal DNA reveals a higher vaccine response in piglets with a richer microbiota, and shows that 23 operational taxonomic units (OTUs) are differentially abundant between high and low IAV-specific IgG producers at D63. A stronger immune response is linked with OTUs assigned to the genus Prevotella and family Muribaculaceae, and a weaker response is linked with OTUs assigned to the genera Helicobacter and Escherichia-Shigella. A set of 81 OTUs accurately predicts IAV-specific IgG and HAI titer levels at all time points, highlighting early and late associations between pre-vaccination fecal microbiota composition and immune response to the vaccine.

摘要

本研究描述了仔猪粪便微生物群与疫苗反应变异性之间的关联，研究使用了98头28日龄（D28）接种甲型流感病毒疫苗并在D49进行加强免疫的仔猪。在D49、D56、D63和D146通过IAV特异性IgG的血清水平和血凝抑制（HAI）试验来测量对疫苗的免疫反应。通过粪便DNA的16S rRNA基因测序对疫苗接种前的微生物群进行分析，结果显示微生物群更丰富的仔猪对疫苗的反应更高，并且表明在D63时，23个可操作分类单元（OTU）在高IAV特异性IgG生产者和低IAV特异性IgG生产者之间存在差异丰富。更强的免疫反应与分配给普雷沃氏菌属和毛螺菌科的OTU相关，而较弱的反应与分配给幽门螺杆菌属和埃希氏菌-志贺氏菌属的OTU相关。一组81个OTU能够准确预测所有时间点的IAV特异性IgG和HAI滴度水平，突出了疫苗接种前粪便微生物群组成与疫苗免疫反应之间的早期和晚期关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7fc2/8298503/9fac6bfb9d50/41541_2021_351_Fig8_HTML.jpg
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