Department of Internal Medicine, Division of Endocrinology and Metabolism, Medical University of Graz, Auenbruggerplatz 15, 8036, Graz, Austria.
Osteoporos Int. 2013 Apr;24(4):1321-32. doi: 10.1007/s00198-012-2076-9. Epub 2012 Jul 10.
We aimed to examine the association of fatal events with osteocalcin (OC) and beta-crosslaps (β-CTX) levels in men. We observed a U-shaped association of OC and β-CTX levels with fatal events in a large cohort of men at high cardiovascular risk.
Accumulating evidence suggests an association of low OC levels with metabolic disturbances. Whether OC levels are related to fatal events is, however, less clear. Further, high β-CTX levels are linked to increased mortality. We aimed to examine the association of fatal events with both OC and β-CTX in men.
We measured OC and β-CTX in 2,271 men referred to coronary angiography (1997-2000).
We observed a U-shaped association of OC and β-CTX with fatal events. Crude hazard ratios (HRs) for all-cause and non-cardiovascular mortality in the highest OC quintile were 1.38 (1.04-1.83) and 1.47 (0.89-2.40), respectively, and 2.11 (1.61-2.75) and 2.06 (1.29-3.29) for men in the lowest compared to the third OC quintile. In multivariate-adjusted models, HRs for all-cause, and non-cardiovascular mortality in the lowest OC quintile were 1.63 (1.23-2.16) and 1.79 (1.10-2.92), respectively, compared to the third OC quintile, whereas the association of high OC with mortality lost its significance. Crude and multivariate-adjusted HRs for cardiovascular mortality in the lowest OC quintile compared to the third OC quintile were 2.08 (1.49-2.90) and 1.74 (1.24-2.46), respectively. Moreover, high as well as low β-CTX levels were independently associated with all-cause (quintile 1 vs. quintile 3: HR 1.42 (1.05-1.92); quintile 5 vs. quintile 3: HR 1.79 (1.31-2.45)) and cardiovascular mortality (quintile 1 vs. quintile 3: HR 1.55 (1.05-2.28); quintile 5 vs. quintile 3: HR 1.85 (1.23-2.77)).
We observed a U-shaped association of OC and β-CTX with fatal events in a large cohort of men at high cardiovascular risk.
探讨骨钙素（OC）和β-胶原特殊序列（β-CTX）水平与男性致命事件的相关性。我们在一个具有较高心血管风险的男性大队列中观察到 OC 和 β-CTX 水平与致命事件之间呈 U 型关联。
越来越多的证据表明，OC 水平低与代谢紊乱有关。然而，OC 水平是否与致命事件有关尚不清楚。此外，β-CTX 水平高与死亡率增加有关。我们旨在研究 OC 和 β-CTX 与男性致命事件的关系。
我们测量了 2271 名接受冠状动脉造影的男性的 OC 和 β-CTX 水平（1997-2000 年）。
我们观察到 OC 和 β-CTX 与致命事件之间呈 U 型关联。最高 OC 五分位数的全因和非心血管死亡率的粗危险比（HR）分别为 1.38（1.04-1.83）和 1.47（0.89-2.40），而最低 OC 五分位数的 HR 分别为 2.11（1.61-2.75）和 2.06（1.29-3.29），与第三 OC 五分位数相比。在多变量调整模型中，最低 OC 五分位数的全因和非心血管死亡率的 HR 分别为 1.63（1.23-2.16）和 1.79（1.10-2.92），而与第三 OC 五分位数相比，OC 低值与死亡率的关联失去了意义。与第三 OC 五分位数相比，最低 OC 五分位数的心血管死亡率的 HR 分别为 2.08（1.49-2.90）和 1.74（1.24-2.46）。此外，高 OC 和低 β-CTX 水平与全因（五分位数 1 与五分位数 3：HR 1.42（1.05-1.92）；五分位数 5 与五分位数 3：HR 1.79（1.31-2.45））和心血管死亡率（五分位数 1 与五分位数 3：HR 1.55（1.05-2.28）；五分位数 5 与五分位数 3：HR 1.85（1.23-2.77））均独立相关。
我们在一个具有较高心血管风险的男性大队列中观察到 OC 和 β-CTX 与致命事件之间呈 U 型关联。
