Bone Metabolic Unit (RETICEF), Endocrinology Division, Hospital Universitario San Cecilio, Av. Dr. Oloriz 16, 18012 Granada, Spain.
Diabetes Metab. 2012 Feb;38(1):76-81. doi: 10.1016/j.diabet.2011.07.008. Epub 2011 Oct 12.
To analyze the relationship between serum levels of osteocalcin and parameters of atherosclerosis in patients with type 2 diabetes mellitus (T2DM).
This cross-sectional study of 78 patients with T2DM evaluated intima-media thickness, and the prevalence of coronary heart disease, atherosclerotic plaques and aortic calcifications. Serum osteocalcin levels were also determined by radioimmunoassay.
The patients' mean age was 57.8±6.4 years (duration of diabetes: 13.4 years; mean HbA(1c) level: 8.01%), and 37.2% had coronary heart disease, 56% had an abnormal intima-media thickness, 26.9% had carotid plaques and 32.1% had aortic calcifications. Coronary heart disease was associated with higher levels of osteocalcin in male vs female patients (1.95±1.36 vs 0.93±0.86 ng/mL, respectively; P=0.006). Also, higher concentrations of osteocalcin were found in female patients with vs without abnormal intima-media thicknesses (2.17±1.84 vs 1.25±0.67 ng/mL, respectively; P=0.042), carotid plaques (2.86±2.10 vs 1.43±1.09 ng/mL, respectively; P=0.03) and aortic calcifications (2.85±1.97 vs 1.26±0.83 ng/mL, respectively; P=0.002). Serum osteocalcin levels were associated with coronary heart disease on multivariate logistic regression (odds ratio: 2.27, 95% confidence interval: 1.21-4.25; P=0.01).
In T2DM patients, serum osteocalcin levels were associated with parameters of atherosclerosis, suggesting that osteocalcin is involved not only in bone metabolism, but also in atherosclerotic disease.
分析 2 型糖尿病（T2DM）患者血清骨钙素水平与动脉粥样硬化参数之间的关系。
本横断面研究纳入了 78 例 T2DM 患者，评估了内膜中层厚度、冠心病患病率、动脉粥样斑块和主动脉钙化情况。采用放射免疫法测定血清骨钙素水平。
患者的平均年龄为 57.8±6.4 岁（糖尿病病程：13.4 年；平均 HbA1c 水平：8.01%），37.2%患有冠心病，56%存在内膜中层厚度异常，26.9%有颈动脉斑块，32.1%有主动脉钙化。与女性患者相比，男性患者的冠心病与更高水平的骨钙素相关（分别为 1.95±1.36 vs 0.93±0.86 ng/mL，P=0.006）。同样，与内膜中层厚度正常的女性患者相比，内膜中层厚度异常的女性患者的骨钙素浓度更高（分别为 2.17±1.84 vs 1.25±0.67 ng/mL，P=0.042），颈动脉斑块患者（分别为 2.86±2.10 vs 1.43±1.09 ng/mL，P=0.03）和主动脉钙化患者（分别为 2.85±1.97 vs 1.26±0.83 ng/mL，P=0.002）。多变量 logistic 回归分析显示，血清骨钙素水平与冠心病相关（优势比：2.27，95%置信区间：1.21-4.25；P=0.01）。
在 T2DM 患者中，血清骨钙素水平与动脉粥样硬化参数相关，提示骨钙素不仅参与骨代谢，还参与动脉粥样硬化疾病。
