Universidad San Pablo-CEU, Departamento de Química, Facultad de Farmacia, Boadilla del Monte, Madrid, Spain.
Org Biomol Chem. 2012 Sep 7;10(33):6665-72. doi: 10.1039/c2ob07185a. Epub 2012 Jul 9.
Cycloisomerization is a totally atom economic procedure which converts dienes and enynes into cyclic molecules. Modification of Grubbs' 2nd generation catalysts by reaction with dimethylformamide provides a new species able to catalyse this transformation. Selection of suitable conditions allowed high yields and selectivity. Studies performed in order to identify the catalytic species point to a non-carbenic ruthenium complex that has lost the phosphine. No hydride signals appeared. In addition, the reaction works with enynes and the new species catalyses efficiently crossed cyclotrimerizations of alkynes with diynes.
环化异构化是一种完全原子经济性的过程，它将二烯和烯炔转化为环状分子。通过与二甲基甲酰胺反应对 Grubbs 第二代催化剂进行修饰，提供了一种能够催化这种转化的新物种。选择合适的条件可以获得高产率和高选择性。为了确定催化物种而进行的研究表明，失去膦的非卡宾型钌配合物是催化活性物种。没有出现氢化物信号。此外，该反应适用于烯炔，并且新物种能够有效地催化炔烃与二炔的交叉环三聚反应。
