Laboratory of Tumor Radiobiology, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, People's Republic of China.
Int J Cancer. 2013 Mar 1;132(5):1162-9. doi: 10.1002/ijc.27719. Epub 2012 Jul 30.
To date, the relationship between obesity and the incidence of lung cancer remains unclear and inconclusive. Thus, we conducted a meta-analysis of published studies to provide a quantitative evaluation of this association. Relevant studies were identified through PubMed and EMBASE databases from 1966 to December 2011, as well as through the reference lists of retrieved articles. A total of 31 articles were included in this meta-analysis. Overall, excess body weight (body mass index, BMI ≥ 25 kg/m(2)) was inversely associated with lung cancer incidence (relative risk, RR = 0.79; 95% confidence interval, CI: 0.73-0.85) compared with normal weight (BMI = 18.5-24.9 kg/m(2)). The association did not change with stratification by sex, study population, study design, and BMI measurement method. However, when stratified by smoking status, the inverse association between excess body weight and lung cancer incidence in current (RR = 0.63, 95% CI: 0.57-0.70) and former (RR = 0.73, 95% CI: 0.58-0.91) smokers was strengthened. In non-smokers, the association was also statistically significant (RR = 0.83, 95% CI: 0.70-0.98), although the link was weakened to some extent. The stratified analyses also showed that excess body weight was inversely associated with squamous cell carcinoma (RR = 0.68, 95% CI: 0.58-0.80) and adenocarcinoma (RR = 0.79, 95% CI: 0.65-0.96). No statistically significant link was found between excess body weight and small cell carcinoma (RR = 0.99, 95% CI: 0.66-1.48). The results of this meta-analysis indicate that overweight and obesity are protective factors against lung cancer, especially in current and former smokers.
迄今为止，肥胖与肺癌发病率之间的关系仍不清楚，没有定论。因此，我们对已发表的研究进行了荟萃分析，以定量评估这种相关性。通过 PubMed 和 EMBASE 数据库，从 1966 年至 2011 年 12 月检索相关研究，并查阅已检索到的文章的参考文献。共有 31 篇文章纳入了本荟萃分析。总体而言，与体重正常（BMI = 18.5-24.9kg/m(2)）相比，超重（BMI≥25kg/m(2)）与肺癌发病率呈负相关（相对危险度 RR = 0.79；95%置信区间 CI：0.73-0.85）。这种相关性不因性别、研究人群、研究设计和 BMI 测量方法的不同而改变。然而，按吸烟状况进行分层时，超重与肺癌发病率之间的负相关性在现吸烟者（RR = 0.63，95% CI：0.57-0.70）和前吸烟者（RR = 0.73，95% CI：0.58-0.91）中有所增强。在不吸烟者中，这种相关性也具有统计学意义（RR = 0.83，95% CI：0.70-0.98），尽管关联在一定程度上有所减弱。分层分析还表明，超重与鳞癌（RR = 0.68，95% CI：0.58-0.80）和腺癌（RR = 0.79，95% CI：0.65-0.96）呈负相关。但超重与小细胞癌（RR = 0.99，95% CI：0.66-1.48）之间无统计学显著关联。本荟萃分析结果表明，超重和肥胖是肺癌的保护因素，尤其是在现吸烟者和前吸烟者中。
