Fletcher Stuckey Pratt Chair in Engineering, Departments of Chemical Engineering and Biomedical Engineering, University of Texas at Austin, 1 University Station C0400, Austin, TX 78712-1062, USA.
Macromol Biosci. 2012 Aug;12(8):1137-44. doi: 10.1002/mabi.201200068. Epub 2012 Jul 6.
CD is used to clearly show the negative impact of common ligands on the overall conformation of BSA, a typical protein template in macromolecularly imprinted polymers. This change occurs at concentrations far lower than those generally used in the literature. These findings are important as they offer insight into a potential fundamental reason for the lack of success in protein imprinting to date despite significant interest from the scientific community.
CD 被用来清楚地显示常见配体对大分子印迹聚合物中典型蛋白质模板 BSA 整体构象的负面影响。这种变化发生在远低于文献中通常使用的浓度下。这些发现很重要，因为它们为迄今为止尽管科学界有很大的兴趣但蛋白质印迹技术缺乏成功的潜在根本原因提供了一些见解。
