Supramolecular Chemistry Group, Department of Organic Chemistry, Ghent University, Krijgslaan 281-S4, 9000 Ghent, Belgium.
Macromol Biosci. 2012 Aug;12(8):1114-23. doi: 10.1002/mabi.201200080. Epub 2012 Jul 6.
The hydrolysis of PEtOx is studied to evaluate the potential toxicity of partially hydrolyzed polymers that might interfere with its increasing popularity for biomedical applications. The hydrolysis of PEtOx is studied in the presence of digestive enzymes (gastric and intestinal) and at 5.8 M hydrochloric acid as a function of temperature (57, 73, 90, and 100 °C). It is found that PEtOx undergoes negligible hydrolysis at 37 °C and that thermal and solution properties are not altered when up to 10% of the polymer backbone is hydrolyzed. Mucosal irritation and cytotoxicity is also absent up to 10% hydrolysis levels. In conclusion, PEtOx will not decompose at physiological conditions, and partial hydrolysis will not limit its biomedical applications.
研究了聚乙氧基（PEtOx）的水解，以评估可能干扰其在生物医学应用中日益普及的部分水解聚合物的潜在毒性。研究了在存在消化酶（胃和肠）和 5.8 M 盐酸的情况下，PEtOx 的水解情况，并作为温度（57、73、90 和 100°C）的函数。结果发现，PEtOx 在 37°C 下几乎不发生水解，并且当聚合物主链的 10%发生水解时，其热和溶液性质不会改变。黏膜刺激和细胞毒性在水解水平达到 10%之前也不存在。总之，PEtOx 不会在生理条件下分解，部分水解不会限制其在生物医学中的应用。
