Pattanashetti Nandini A, Kariduraganavar Mahadevappa Y, Rao Arjun Sunil, Savadi Amruta, Pali Maruti, Sonavane Siddharth
Department of Chemistry, Dayananda Sagar Academy of Technology and Management, Bangalore, 560082, India.
Department of Chemistry, Karnatak University Dharwad, Dharwad, 580003, India.
Heliyon. 2024 Dec 14;11(1):e41259. doi: 10.1016/j.heliyon.2024.e41259. eCollection 2025 Jan 15.
The selection of a biomaterial plays a very important role for the development of scaffolds for biomedical applications. Amidst, the development of nanofibrous scaffolds through electrospinning technique by selecting a suitable polymer is of more importance. Poly (2-ethyl-2-oxazoline) (PEOX) is one among the selected polymers that can be employed for electrospinning for the development of scaffolds for biomedical applications. PEOX is a water-soluble polymer which is highly desirable for biomedical applications. At the same time, PEOX is soluble in the mixture of organic solvents as well. In view of this, the present study is the preliminary study of using PEOX for the development of scaffolds by using electrospinning technique and to check its potentiality for biomedical application like tissue engineering for the future research. The PEOX scaffolds were fabricated using electrospinning process using water and organic solvents, and the effect of solvent was studied on the morphology and physical properties of the developed scaffolds. The Scanning Electron Microscopic results of the scaffolds showed a uniform nanofibrous structure in case of aqueous PEOX solution, whereas microfibrous structure was obtained for organic solvent. Wettability of the scaffolds was observed by contact angle measurement, which revealed that the hydrophilicity of the PEOX (aq.) scaffold was higher with the contact angle of 55.2° as compared to PEOX (org.) scaffold with the contact angle of 70.38°. Further, the mechanical strength of the scaffolds was calculated in terms of Young's modulus values and it was observed that the PEOX (org.) demonstrated a higher tensile strength of 1.9 MPa compared to PEOX (aq.) scaffold with 1.02 MPa respectively. The results thus clearly conclude that the nature of solvents greatly affect the electrospinning process of PEOX and thereby the properties of the developed PEOX scaffolds based on the solvent. Further, we can say that the developed PEOX scaffolds possess suitable properties to be employed for biomedical applications like tissue engineering.
生物材料的选择对生物医学应用支架的开发起着非常重要的作用。其中，通过选择合适的聚合物利用静电纺丝技术开发纳米纤维支架更为重要。聚（2-乙基-2-恶唑啉）（PEOX）是可用于静电纺丝以开发生物医学应用支架的所选聚合物之一。PEOX是一种水溶性聚合物，这在生物医学应用中非常理想。同时，PEOX也可溶于有机溶剂混合物。鉴于此，本研究是关于使用PEOX通过静电纺丝技术开发支架并检查其在未来研究中用于组织工程等生物医学应用的潜力的初步研究。使用水和有机溶剂通过静电纺丝工艺制备了PEOX支架，并研究了溶剂对所开发支架的形态和物理性能的影响。支架的扫描电子显微镜结果显示，在PEOX水溶液的情况下呈现均匀的纳米纤维结构，而在有机溶剂的情况下获得的是微纤维结构。通过接触角测量观察了支架的润湿性，结果表明，PEOX（水相）支架的亲水性更高，接触角为55.2°，而PEOX（有机相）支架的接触角为70.38°。此外，根据杨氏模量值计算了支架的机械强度，结果观察到，PEOX（有机相）的拉伸强度为1.9MPa，高于PEOX（水相）支架的1.02MPa。因此，结果清楚地表明，溶剂的性质极大地影响了PEOX的静电纺丝过程，从而影响了基于溶剂所开发的PEOX支架的性能。此外，我们可以说所开发的PEOX支架具有适用于组织工程等生物医学应用的合适性能。
