Vargas-Alarcon Gilberto, Ramirez-Bello Julian, Angeles-Martinez Javier, Rodriguez-Perez Jose Manuel, Perez-Hernandez Nonanzit, Posadas-Romero Carlos, Jorge-Galarza Esteban, Ocampo-Arcos Wendy Angelica, Obil-Chavarria Claudia, Fragoso Jose Manuel
Department of Molecular Biology and Interventional Genetic Study Group, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Laboratory of Genomic Medicine, Unit of Research, Hospital Juárez de Mexico, Mexico City, Mexico.
Immunol Lett. 2014 Dec;162(2 Pt B):247-51. doi: 10.1016/j.imlet.2014.10.003. Epub 2014 Oct 14.
The CLEC16A gene has an important role in the immune activation and regulation inflammatory. This gene encodes to C-type lectin domain that is involved in the recognition of DAMPS. The aim of this study was assess the CLEC16A gene polymorphisms in the risk of developing ACS in a group of patients. Four rs12708716, rs12917716, rs6498142 and rs9925481 (positions 146529 A>G, 155804 G>C, 47905 C>G and 64135 C>T, respectively) single nucleotide polymorphisms of CLEC16A gene were analyzed by TaqMan assays in a group of 452 patients with ACS and 456 healthy controls. The analysis was performed on the total group of individuals and then in groups of men and women separately. Under co-dominant model adjusted by cardiovascular risk factors the rs12708716 (146529 A>G) and rs12917716 (155804 G>C) polymorphisms were significantly associated with decrease risk of ACS in men (OR=0.16, PCo-dom=0.027 and OR=0.37, PCo-dom=0.016, respectively). In summary, our data suggests that two polymorphisms of the CLEC16A gene play an important role in the developing of ACS in men.
CLEC16A基因在免疫激活和炎症调节中起重要作用。该基因编码参与识别损伤相关分子模式（DAMPs）的C型凝集素结构域。本研究的目的是评估一组患者中CLEC16A基因多态性与发生急性冠状动脉综合征（ACS）风险的关系。通过TaqMan分析对452例ACS患者和456例健康对照者组成的队列分析了CLEC16A基因的4个单核苷酸多态性rs12708716、rs12917716、rs6498142和rs9925481（分别对应位置146529 A>G、155804 G>C、47905 C>G和64135 C>T）。对所有个体进行分析，然后分别对男性和女性组进行分析。在经心血管危险因素校正的共显性模型下，rs12708716（146529 A>G）和rs12917716（155804 G>C）多态性与男性ACS风险降低显著相关（OR分别为0.16，PCo-dom = 0.027；OR为0.37，PCo-dom = 0.016）。总之，我们的数据表明CLEC16A基因的两个多态性在男性ACS的发生中起重要作用。
