超顺磁性氧化铁纳米颗粒：在多发性硬化症的诊断和治疗中的应用前景。
Superparamagnetic iron oxide nanoparticles: promises for diagnosis and treatment of multiple sclerosis.
机构信息
National Cell Bank, Pasteur Institute of Iran, Tehran, 11365-8639, Iran.
出版信息
ACS Chem Neurosci. 2011 Mar 16;2(3):118-40. doi: 10.1021/cn100100e. Epub 2011 Feb 4.
Abstract
Smart superparamagnetic iron oxide nanoparticles (SPIONs) are the most promising candidate for theragnosis (i.e., diagnosis and treatment) of multiple sclerosis. A deep understanding of the dynamics of the in vivo neuropathology of multiple sclerosis can be achieved by improving the efficiency of various medical techniques (e.g., positron emission tomography and magnetic resonance imaging) using multimodal SPIONs. In this Review, recent advances and challenges in the development of smart SPIONs for theragnostic applications are comprehensively described. In addition, critical outlines of emerging developments are provided from the points of view of both clinicians and nanotechnologists.
摘要
智能超顺磁性氧化铁纳米颗粒（SPIONs）是治疗多发性硬化症（即诊断和治疗）最有前途的候选者。通过使用多模态 SPIONs 提高各种医学技术（例如正电子发射断层扫描和磁共振成像）的效率，可以深入了解多发性硬化症的体内神经病理学动态。在这篇综述中，全面描述了用于治疗应用的智能 SPIONs 的最新进展和挑战。此外，从临床医生和纳米技术人员的角度出发，提供了新兴发展的关键要点。
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