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2
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6
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Preterm Birth: Long Term Cardiovascular and Renal Consequences.早产：长期心血管和肾脏后果。
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本文引用的文献

1
Low birth weight is associated with earlier onset of end-stage renal disease in Danish patients with autosomal dominant polycystic kidney disease.低出生体重与丹麦常染色体显性多囊肾病患者终末期肾病的发病较早有关。
Kidney Int. 2012 May;81(9):919-24. doi: 10.1038/ki.2011.459. Epub 2012 Feb 1.
2
Intrauterine growth restriction is associated with persistent aortic wall thickening and glomerular proteinuria during infancy.宫内生长受限与婴儿期持续的主动脉壁增厚和肾小球蛋白尿有关。
Kidney Int. 2011 Jul;80(1):119-23. doi: 10.1038/ki.2011.99. Epub 2011 Apr 13.
3
Maternal undernutrition and the offspring kidney: from fetal to adult life.母体营养不足与后代肾脏：从胎儿到成年期。
Braz J Med Biol Res. 2010 Nov;43(11):1010-8. doi: 10.1590/s0100-879x2010007500113. Epub 2010 Oct 29.
4
Maternal protein restriction reduces angiotensin II AT(1) and AT(2) receptor expression in the fetal rat kidney.母体蛋白限制可降低胎鼠肾脏中血管紧张素 II AT(1)和 AT(2)受体的表达。
Kidney Blood Press Res. 2010;33(4):251-9. doi: 10.1159/000317739. Epub 2010 Jul 2.
5
Prematurity, small for gestational age and perinatal parameters in children with congenital, hereditary and acquired chronic kidney disease.先天性、遗传性和获得性慢性肾病儿童的早产、小于胎龄儿和围产期参数。
Nephrol Dial Transplant. 2010 Dec;25(12):3918-24. doi: 10.1093/ndt/gfq300. Epub 2010 May 31.
6
The clinical importance of nephron mass.肾小球数量的临床重要性。
J Am Soc Nephrol. 2010 Jun;21(6):898-910. doi: 10.1681/ASN.2009121248. Epub 2010 Feb 11.
7
Accelerated senescence in kidneys of low-birth-weight rats after catch-up growth.追赶生长后低出生体重大鼠肾脏的加速衰老
Am J Physiol Renal Physiol. 2009 Dec;297(6):F1697-705. doi: 10.1152/ajprenal.00462.2009. Epub 2009 Oct 14.
8
Role of the kidney in the prenatal and early postnatal programming of hypertension.肾脏在高血压的产前和产后早期编程中的作用。
Am J Physiol Renal Physiol. 2010 Feb;298(2):F235-47. doi: 10.1152/ajprenal.00288.2009. Epub 2009 Sep 30.
9
Expression of renin-angiotensin system signalling compounds in maternal protein-restricted rats: effect on renal sodium excretion and blood pressure.在母体蛋白限制的大鼠中肾素-血管紧张素系统信号化合物的表达：对肾钠排泄和血压的影响。
Nephrol Dial Transplant. 2010 Feb;25(2):380-8. doi: 10.1093/ndt/gfp505. Epub 2009 Sep 30.
10
Impact of gestational age and birth weight on amikacin clearance on day 1 of life.胎龄和出生体重对生后第 1 天阿米卡星清除率的影响。
Clin J Am Soc Nephrol. 2009 Nov;4(11):1774-8. doi: 10.2215/CJN.02230409. Epub 2009 Aug 27.

出生体重对成年期肾脏发育及肾脏疾病的影响：实验与临床证据

Influence of birth weight on the renal development and kidney diseases in adulthood: experimental and clinical evidence.

作者信息

Franco Maria C P, Oliveira Vanessa, Ponzio Beatriz, Rangel Marina, Palomino Zaira, Gil Frida Zaladek

机构信息

Division of Nephrology, School of Medicine, Federal University of São Paulo, 04023-062 São Paulo, SP, Brazil.

出版信息

Int J Nephrol. 2012;2012:608025. doi: 10.1155/2012/608025. Epub 2012 Jun 17.

DOI:10.1155/2012/608025
PMID:22778952
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3385608/
Abstract

Several clinical and experimental studies support the hypothesis that foetal programming is an important determinant of nephropathy, hypertension, coronary heart disease, and type 2 diabetes during adulthood. In this paper, the renal repercussions of foetal programming are emphasised, and the physiopathological mechanisms are discussed. The programming of renal diseases is detailed based on the findings of kidney development and functional parameters.

摘要

多项临床和实验研究支持这样一种假说，即胎儿编程是成年期肾病、高血压、冠心病和2型糖尿病的重要决定因素。本文着重阐述了胎儿编程对肾脏的影响，并讨论了其生理病理机制。基于肾脏发育和功能参数的研究结果，详细介绍了肾脏疾病的编程情况。