Department of Chemistry, 232 Choppin Hall, Louisiana State University , Baton Rouge, Louisiana 70803, United States.
Org Lett. 2012 Jul 20;14(14):3676-9. doi: 10.1021/ol301520d. Epub 2012 Jul 10.
Activation of primary aliphatic alcohols with triphosgene and triethylamine mixtures afforded either alkyl chloride or diethylcarbamate products, and the switch in selectivity appeared to be driven by sterics. The reaction conditions to achieve this highly useful transformation were unexceptionally mild and readily tolerated by a wide range of sensitive functionalities.
三光气和三乙胺混合物对伯脂肪醇的活化生成了烷基氯或二乙酯基碳酸酯产物，选择性的转换似乎是由空间位阻驱动的。实现这种非常有用的转化的反应条件异常温和，广泛的敏感官能团都能很好地耐受。
