Department of Chemistry , Louisiana State University , 232 Choppin Hall , Baton Rouge , Louisiana 70803 , United States.
J Org Chem. 2018 Mar 16;83(6):3367-3377. doi: 10.1021/acs.joc.7b03197. Epub 2018 Mar 1.
Herein we report a novel synthetic reaction to convert unactivated terminal aliphatic epoxide to alkyl vicinal dichloride based on triphosgene-pyridine activation. Our methodology is operationally simple and readily tolerated by a broad of scope of substrates as well as protecting groups. Furthermore, these mild conditions generally yield clean reaction mixtures that are free of byproducts upon aqueous workup.
在此，我们报告了一种新型的合成反应，即在三光气-吡啶活化的作用下，将非活化的末端脂环族环氧化物转化为烷基偕二氯化物。我们的方法操作简单，对广泛的底物和保护基具有良好的耐受性。此外，这些温和的条件通常能得到干净的反应混合物，在水相处理后没有副产物。
