调控神经退行性病变过程的表观遗传机制。
Epigenetic mechanisms governing the process of neurodegeneration.
机构信息
Roslyn and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, New York, NY 10461, USA.
出版信息
Mol Aspects Med. 2013 Jul-Aug;34(4):875-82. doi: 10.1016/j.mam.2012.06.011. Epub 2012 Jul 7.
Abstract
Studies elucidating how and why neurodegeneration unfolds suggest that a complex interplay between genetic and environmental factors is responsible for disease pathogenesis. Recent breakthroughs in the field of epigenetics promise to advance our understanding of these mechanisms and to promote the development of useful and effective pre-clinical risk stratification strategies, molecular diagnostic and prognostic methods, and disease-modifying treatments.
摘要
阐明神经退行性变发生机制和原因的研究表明，遗传和环境因素之间的复杂相互作用是导致疾病发病机制的原因。表观遗传学领域的最新突破有望增进我们对这些机制的理解，并促进有用和有效的临床前风险分层策略、分子诊断和预后方法以及疾病修饰治疗方法的开发。
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