VIB Center for Brain and Disease Research, Herestraat 49, 3000 Leuven, Belgium.
KU Leuven, Department of Neurosciences, Leuven Institute for Neuroscience and Disease, (LIND), Herestraat 49, 3000 Leuven, Belgium.
Nat Rev Neurosci. 2017 Oct;18(10):627-640. doi: 10.1038/nrn.2017.90. Epub 2017 Aug 17.
The emerging complexity of the transcriptional landscape poses great challenges to our conventional preconceptions of how the genome regulates brain function and dysfunction. Non-protein-coding RNAs (ncRNAs) confer a high level of intricate and dynamic regulation of various molecular processes in the CNS and they have been implicated in neurodevelopment and brain ageing, as well as in synapse function and cognitive performance, in both health and disease. ncRNA-mediated processes may be involved in various aspects of the pathogenesis of neurodegenerative disorders. Understanding these events may help to develop novel diagnostic and therapeutic tools. Here, we provide an overview of the complex mechanisms that are affected by the diverse ncRNA classes that have been implicated in neurodegeneration.
转录景观的新兴复杂性给我们传统的观念带来了巨大的挑战，即基因组如何调节大脑功能和功能障碍。非蛋白编码 RNA（ncRNA）对中枢神经系统中各种分子过程进行高度复杂和动态的调节，它们与神经发育和大脑衰老以及突触功能和认知表现有关，无论是在健康还是疾病中。ncRNA 介导的过程可能涉及神经退行性疾病发病机制的各个方面。了解这些事件可能有助于开发新的诊断和治疗工具。在这里，我们概述了受各种与神经退行性变有关的 ncRNA 类影响的复杂机制。
