Department of Medicinal Chemistry, Faculty of Pharmaceutical Sciences, Universitetsparken 2, 2100 Copenhagen, University of Copenhagen, Denmark.
J Ethnopharmacol. 2012 Jun 14;141(3):1077-9. doi: 10.1016/j.jep.2012.03.035.
The roots of Rubia tibetica are chewed as an antidote to anaphylaxis caused by bites of the tick Ornithodoros lahorensis by the Wakhi people in Afghanistan.
To test whether Rubia tibetica possess anti-histamine effect.
Water and ethanol extracts of roots of Rubia tibetica were tested for anti-histamine effect on the H1-receptor in the guinea pig ileum assay. Fixed concentrations of plant extract with increasing concentrations of histamine were examined. Mepyramine was used as control.
The ethanol extract of Rubia tibetica showed dose-dependent anti-histamine effect, whereas the water extract had little activity. The chewing of Rubia tibetica roots may alleviate the fatal swelling of the tongue during anaphylaxis.
阿富汗瓦克人咀嚼西藏茜草根作为抗蜱 Ornithodoros lahorensis 叮咬引起过敏反应的解毒剂。
测试西藏茜草是否具有抗组胺作用。
用水和乙醇提取西藏茜草根，在豚鼠回肠试验中测试其对 H1 受体的抗组胺作用。用固定浓度的植物提取物与逐渐增加浓度的组胺进行检查。甲哌啶作为对照。
西藏茜草的乙醇提取物显示出剂量依赖性的抗组胺作用，而水提取物活性较小。咀嚼西藏茜草根可能会减轻过敏反应时舌部致命肿胀的程度。
