通过铑催化的[5 + 1]环加成反应合成 welwitindolinones 的功能化环己烯酮核心。
Synthesis of functionalized cyclohexenone core of welwitindolinones via rhodium-catalyzed [5 + 1] cycloaddition.
机构信息
School of Pharmacy, University of Wisconsin , Madison, Wisconsin 53705, United States.
出版信息
Org Lett. 2012 Jul 20;14(14):3756-9. doi: 10.1021/ol301614v. Epub 2012 Jul 11.
Abstract
The cyclohexenone core of welwitindolinones was synthesized by a Rh(I)-catalyzed [5 + 1]-cycloaddition of an allenylcyclopropane with CO. A pentasubstituted cyclopropane was prepared successfully by a Rh(II)-catalyzed intramolecular cyclopropanation of alkenes with chlorodiazoacetates.
摘要
威罗替丁酮类化合物的环己烯酮核心结构是通过 Rh(I)催化的烯丙基环丙烷与 CO 的 [5 + 1]-环加成反应合成的。通过 Rh(II)催化烯烃与重氮乙酸酯的分子内环丙烷化反应，成功制备了一个五取代的环丙烷。
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