Pd(0)催化的含亲核基团吲哚与丙炔碳酸酯之间的烯基化和烯丙基去芳构化反应。

Pd(0)-catalyzed alkenylation and allylic dearomatization reactions between nucleophile-bearing indoles and propargyl carbonate.

机构信息

State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences , 345 Lingling Lu, Shanghai 200032, China.

出版信息

Org Lett. 2014 Aug 1;16(15):3919-21. doi: 10.1021/ol501704q. Epub 2014 Jul 3.

DOI:10.1021/ol501704q

PMID:24992703

Abstract

Spiroindolenine derivatives were synthesized by intermolecular Pd-catalyzed dearomatization of indoles. The reaction between nucleophile bearing indoles and propargyl carbonate proceeds in a cascade fashion providing spiroindolenines or spiroindolines in good to excellent yields.

摘要

通过分子间 Pd 催化的吲哚去芳构化反应合成了螺吲哚啉衍生物。带亲核试剂的吲哚与丙炔碳酸酯之间的反应以级联方式进行，以良好至优异的收率得到螺吲哚啉或螺吲哚啉。