骨骼作为内分泌器官。
Bone as an endocrine organ.
机构信息
Center for Clinical and Translational Research, Maine Medical Center Research Institute, 81 Research Dr, Scarborough, Maine 04074, USA.
出版信息
Endocr Pract. 2012 Sep-Oct;18(5):758-62. doi: 10.4158/EP12141.RA.
OBJECTIVE
To review the recent evidence that has emerged supporting the role of bone as an endocrine organ.
METHODS
This review will detail how bone has emerged as a bona fide endocrine "gland," and with that, the potential therapeutic implications that could be realized for this hormone-secreting tissue by detailing the evidence in the literature supporting this view.
RESULTS
The recent advances point to the skeleton as an endocrine organ that modulates glucose tolerance and testosterone production by secretion of the bone-specific protein osteocalcin.
CONCLUSIONS
Bone has classically been viewed as an inert structure that is necessary for mobility, calcium homeostasis, and maintenance of the hematopoietic niche. Recent advances in bone biology using complex genetic manipulations in mice have highlighted the importance of bone not only as a structural scaffold to support the human body, but also as a regulator of a number of metabolic processes that are independent of mineral metabolism.
目的
综述近年来支持骨骼作为内分泌器官的作用的证据。
方法
本综述将详细介绍骨骼如何成为名副其实的内分泌“腺体”，以及骨骼通过分泌特异性骨蛋白骨钙素来调节葡萄糖耐量和睾酮产生，由此产生的潜在治疗意义。详细阐述了支持这一观点的文献中的证据。
结果
最近的进展表明，骨骼是一种内分泌器官，通过分泌特异性骨蛋白骨钙素来调节葡萄糖耐量和睾酮产生。
结论
骨骼传统上被视为一种惰性结构，对于运动、钙稳态和造血龛的维持是必需的。使用复杂的遗传操作在小鼠中进行的骨生物学的最新进展强调了骨骼的重要性，它不仅是支撑人体的结构支架，也是许多与矿物质代谢无关的代谢过程的调节剂。
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