Centre for Vision Research, Department of Ophthalmology and Westmead Millennium Institute, University of Sydney, Sydney, Australia.
Invest Ophthalmol Vis Sci. 2012 Aug 7;53(9):5227-30. doi: 10.1167/iovs.12-9422.
Previous studies have reported high right-left eye correlation in retinal vessel caliber. We test the hypothesis that right-left correlation in retinal vessel caliber would be reduced in anisometropic compared with emmetropic children.
Retinal arteriolar and venular calibers were measured in 12-year-old children. Three groups were selected: group 1, both eyes emmetropic (n = 214); group 2, right-left spherical equivalent refraction (SER) difference ≥1.00 but <2.00 diopter (D) (n = 35); and group 3, right-left SER difference ≥2.00 D (n = 32). Pearson's correlations between the two eyes were compared between group 1 and group 2 or 3. Associations between right-left difference in refractive error and right-left difference in caliber measurements were assessed using linear regression models.
Right-left correlation in group 1 was 0.57 for central retinal arteriolar equivalent (CRAE) and 0.70 for central retinal venular equivalent (CRVE) compared with 0.60 and 0.82 for CRAE and CRVE, respectively, in group 2 (P = 0.42 and P = 0.08), and 0.36 and 0.52, respectively, in group 3 (P = 0.08 and P = 0.07, referenced to group 1). Each 1.00-D increase in right-left SER difference was associated with a 0.74-μm increase in mean CRAE difference (P = 0.02) and a 1.23-μm increase in mean CRVE difference between the two eyes (P = 0.002). Each 0.1-mm increase in right-left difference in axial length was associated with a 0.21-μm increase in the mean difference in CRAE (P = 0.01) and a 0.42-μm increase in the mean difference in CRVE (P < 0.0001) between the two eyes.
Refractive error ≥2.00 D may contribute to variation in measurements of retinal vessel caliber.
先前的研究报告称视网膜血管口径的左右眼相关性很高。我们检验了这样一个假设，即与正视眼儿童相比，屈光参差儿童的视网膜血管口径的左右眼相关性会降低。
测量了 12 岁儿童的视网膜动脉和小静脉的口径。选择了三组：第 1 组，双眼均正视（n=214）；第 2 组，双眼球镜等效屈光度（SER）差异≥1.00 但 <2.00 屈光度（D）（n=35）；第 3 组，双眼 SER 差异≥2.00 D（n=32）。比较第 1 组与第 2 组或第 3 组之间双眼之间的 Pearson 相关性。使用线性回归模型评估屈光不正的左右差异与口径测量的左右差异之间的关系。
第 1 组中央视网膜动脉等效（CRAE）和中央视网膜静脉等效（CRVE）的左右相关性分别为 0.57 和 0.70，而第 2 组分别为 0.60 和 0.82（P=0.42 和 P=0.08），第 3 组分别为 0.36 和 0.52（P=0.08 和 P=0.07，参考第 1 组）。双眼 SER 差异每增加 1.00 D，平均 CRAE 差异增加 0.74 μm（P=0.02），双眼平均 CRVE 差异增加 1.23 μm（P=0.002）。双眼轴向长度差异每增加 0.1 mm，平均 CRAE 差异增加 0.21 μm（P=0.01），平均 CRVE 差异增加 0.42 μm（P<0.0001）。
屈光不正≥2.00 D 可能会导致视网膜血管口径测量值的变化。
