Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2012 Jul;27(7):818-21. doi: 10.3346/jkms.2012.27.7.818. Epub 2012 Jun 29.
Bullous systemic lupus erythematosus (SLE) is a kind of LE-non-specific bullous skin disease that is rarely induced by a medication. We describe the first case of bullous SLE to develop after administration of methimazole. A 31-yr-old woman presented with generalized erythematous patches, multiple bullae, arthralgia, fever, conjunctivitis, and hemolytic anemia. Biopsy of her bulla showed linear deposition of lgG, lgA, C3, fibrinogen, and C1q at dermo-epidermal junction. She was diagnosed as bullous SLE and treated with prednisolone, dapsone, hydroxychloroquine, and methotrexate. Our experience suggests that SLE should be considered as a differential diagnosis when bullous skin lesions develop in patients being treated for hyperthyroidism.
大疱性系统性红斑狼疮（SLE）是一种非特异性 LE 大疱性皮肤疾病，很少由药物诱发。我们描述了首例甲巯咪唑治疗后发生的大疱性 SLE 病例。一名 31 岁女性出现全身红斑斑块、多腔水疱、关节痛、发热、结膜炎和溶血性贫血。她水疱的活检显示 lgG、lgA、C3、纤维蛋白原和 C1q 在表皮交界处呈线性沉积。她被诊断为大疱性 SLE，并接受泼尼松、氨苯砜、羟氯喹和甲氨蝶呤治疗。我们的经验表明，当治疗甲状腺功能亢进症的患者出现水疱性皮肤损伤时，应考虑 SLE 作为鉴别诊断。
